Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis

Megremis, Walker at al. identify immunogenic epitopes in dermatomyositis patients. They identify antibodies recognizing a wider diversity of microbial antigens including poxviruses, and autoantibodies recognizing a large portion of the human proteome. Shared epitope homology between viral and human...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Spyridon Megremis, Thomas D. J. Walker, Xiaotong He, James O’Sullivan, William E. R. Ollier, Hector Chinoy, Neil Pendleton, Antony Payton, Lynne Hampson, Ian Hampson, Janine A. Lamb
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ba4a509bcb374d539d4a36a7507e15fc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ba4a509bcb374d539d4a36a7507e15fc
record_format	dspace
spelling	oai:doaj.org-article:ba4a509bcb374d539d4a36a7507e15fc2021-12-02T11:44:59ZAnalysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis10.1038/s42003-021-01932-62399-3642https://doaj.org/article/ba4a509bcb374d539d4a36a7507e15fc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01932-6https://doaj.org/toc/2399-3642Megremis, Walker at al. identify immunogenic epitopes in dermatomyositis patients. They identify antibodies recognizing a wider diversity of microbial antigens including poxviruses, and autoantibodies recognizing a large portion of the human proteome. Shared epitope homology between viral and human proteins suggests that molecular mimicry and epitope spreading events may play a role in dermatomyositis pathogenesis.Spyridon MegremisThomas D. J. WalkerXiaotong HeJames O’SullivanWilliam E. R. OllierHector ChinoyNeil PendletonAntony PaytonLynne HampsonIan HampsonJanine A. LambNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Spyridon Megremis Thomas D. J. Walker Xiaotong He James O’Sullivan William E. R. Ollier Hector Chinoy Neil Pendleton Antony Payton Lynne Hampson Ian Hampson Janine A. Lamb Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis
description	Megremis, Walker at al. identify immunogenic epitopes in dermatomyositis patients. They identify antibodies recognizing a wider diversity of microbial antigens including poxviruses, and autoantibodies recognizing a large portion of the human proteome. Shared epitope homology between viral and human proteins suggests that molecular mimicry and epitope spreading events may play a role in dermatomyositis pathogenesis.
format	article
author	Spyridon Megremis Thomas D. J. Walker Xiaotong He James O’Sullivan William E. R. Ollier Hector Chinoy Neil Pendleton Antony Payton Lynne Hampson Ian Hampson Janine A. Lamb
author_facet	Spyridon Megremis Thomas D. J. Walker Xiaotong He James O’Sullivan William E. R. Ollier Hector Chinoy Neil Pendleton Antony Payton Lynne Hampson Ian Hampson Janine A. Lamb
author_sort	Spyridon Megremis
title	Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis
title_short	Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis
title_full	Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis
title_fullStr	Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis
title_full_unstemmed	Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis
title_sort	analysis of human total antibody repertoires in tif1γ autoantibody positive dermatomyositis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba4a509bcb374d539d4a36a7507e15fc
work_keys_str_mv	AT spyridonmegremis analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT thomasdjwalker analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT xiaotonghe analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT jamesosullivan analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT williamerollier analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT hectorchinoy analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT neilpendleton analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT antonypayton analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT lynnehampson analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT ianhampson analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis AT janinealamb analysisofhumantotalantibodyrepertoiresintif1gautoantibodypositivedermatomyositis
_version_	1718395306201055232

Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis

Ejemplares similares