Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis

Abstract Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the risk of mortality among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA) is largely unknown. PLWHA are unique due to their altered immune s...

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Autores principales:	Paddy Ssentongo, Emily S. Heilbrunn, Anna E. Ssentongo, Shailesh Advani, Vernon M. Chinchilli, Jonathan J. Nunez, Ping Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba4c0e45ea1344c29e635af9dd70afe9
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spelling	oai:doaj.org-article:ba4c0e45ea1344c29e635af9dd70afe92021-12-02T17:05:46ZEpidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis10.1038/s41598-021-85359-32045-2322https://doaj.org/article/ba4c0e45ea1344c29e635af9dd70afe92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85359-3https://doaj.org/toc/2045-2322Abstract Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the risk of mortality among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA) is largely unknown. PLWHA are unique due to their altered immune system from their history of chronic HIV infection and their use of antiretroviral therapy, some of which have been used experimentally to treat coronavirus disease 2019 (COVID-19). Therefore, we conducted a systematic review and meta-analysis to assess the epidemiology of SARS-COV-2/HIV coinfection and estimate associated mortality from COVID-19 (Prospero Registration ID: CRD42020187980). PubMed, SCOPUS, OVID and Cochrane Library databases, and medRxiv preprint repositories were searched from January 1, 2020, to December 12, 2020. Data were extracted from studies reporting COVID-19 attack and mortality rates in PLWHA compared to their HIV-negative counterparts. Pooled attack and mortality risks were quantified using random-effects models. We identified 22 studies that included 20,982,498 participants across North America, Africa, Europe, and Asia. The median age was 56 years, and 50% were male. HIV-positive persons had a significantly higher risk of SARS-CoV-2 infection [risk ratio (RR) 1.24, 95% CI 1.05–1.46)] and mortality from COVID-19 (RR 1.78, 95% CI 1.21–2.60) than HIV-negative individuals. The beneficial effects of tenofovir and protease-inhibitors in reducing the risk of SARS-CoV-2 infection and death from COVID-19 in PLWHA remain inconclusive. HIV remains a significant risk factor for acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality from COVID-19. In support of the current Centers for Disease Control and Prevention (CDC) guidelines, persons with HIV need priority consideration for the SARS-CoV-2 vaccine.Paddy SsentongoEmily S. HeilbrunnAnna E. SsentongoShailesh AdvaniVernon M. ChinchilliJonathan J. NunezPing DuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paddy Ssentongo Emily S. Heilbrunn Anna E. Ssentongo Shailesh Advani Vernon M. Chinchilli Jonathan J. Nunez Ping Du Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
description	Abstract Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the risk of mortality among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA) is largely unknown. PLWHA are unique due to their altered immune system from their history of chronic HIV infection and their use of antiretroviral therapy, some of which have been used experimentally to treat coronavirus disease 2019 (COVID-19). Therefore, we conducted a systematic review and meta-analysis to assess the epidemiology of SARS-COV-2/HIV coinfection and estimate associated mortality from COVID-19 (Prospero Registration ID: CRD42020187980). PubMed, SCOPUS, OVID and Cochrane Library databases, and medRxiv preprint repositories were searched from January 1, 2020, to December 12, 2020. Data were extracted from studies reporting COVID-19 attack and mortality rates in PLWHA compared to their HIV-negative counterparts. Pooled attack and mortality risks were quantified using random-effects models. We identified 22 studies that included 20,982,498 participants across North America, Africa, Europe, and Asia. The median age was 56 years, and 50% were male. HIV-positive persons had a significantly higher risk of SARS-CoV-2 infection [risk ratio (RR) 1.24, 95% CI 1.05–1.46)] and mortality from COVID-19 (RR 1.78, 95% CI 1.21–2.60) than HIV-negative individuals. The beneficial effects of tenofovir and protease-inhibitors in reducing the risk of SARS-CoV-2 infection and death from COVID-19 in PLWHA remain inconclusive. HIV remains a significant risk factor for acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality from COVID-19. In support of the current Centers for Disease Control and Prevention (CDC) guidelines, persons with HIV need priority consideration for the SARS-CoV-2 vaccine.
format	article
author	Paddy Ssentongo Emily S. Heilbrunn Anna E. Ssentongo Shailesh Advani Vernon M. Chinchilli Jonathan J. Nunez Ping Du
author_facet	Paddy Ssentongo Emily S. Heilbrunn Anna E. Ssentongo Shailesh Advani Vernon M. Chinchilli Jonathan J. Nunez Ping Du
author_sort	Paddy Ssentongo
title	Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
title_short	Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
title_full	Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
title_fullStr	Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
title_full_unstemmed	Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis
title_sort	epidemiology and outcomes of covid-19 in hiv-infected individuals: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba4c0e45ea1344c29e635af9dd70afe9
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Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis

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