Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism

Intradermal injection of botulinum neurotoxin is a frequently performed procedure in aesthetic dermatology to improve facial skin tone, texture, fine wrinkles, and enlarged pores. In practice, botulinum neurotoxin type A is also used to reduce skin oiliness of the face. There is increasing evidence...

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Autores principales:	Nark-Kyoung Rho, Young-Chun Gil
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acetylcholine acne vulgaris botulinum toxins cholinergic receptors non-neuronal cholinergic system oily skin Medicine R
Acceso en línea:	https://doaj.org/article/ba4e63199f4f4487a4cee440c8214863
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id	oai:doaj.org-article:ba4e63199f4f4487a4cee440c8214863
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spelling	oai:doaj.org-article:ba4e63199f4f4487a4cee440c82148632021-11-25T19:09:05ZBotulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism10.3390/toxins131108172072-6651https://doaj.org/article/ba4e63199f4f4487a4cee440c82148632021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/817https://doaj.org/toc/2072-6651Intradermal injection of botulinum neurotoxin is a frequently performed procedure in aesthetic dermatology to improve facial skin tone, texture, fine wrinkles, and enlarged pores. In practice, botulinum neurotoxin type A is also used to reduce skin oiliness of the face. There is increasing evidence that acetylcholine plays specific roles in sebum production, suggesting that botulinum neurotoxin type A may reduce sebum production by interfering with cholinergic transmission between sebaceous glands and autonomic nerve terminals. Botulinum neurotoxins can also inhibit several pathogenetic components of acne development, suggesting that botulinum neurotoxins can be used as a safe and effective treatment modality for acne and other skin disorders related to overactivity of sebaceous glands. This review aims to explore the current evidence behind the treatment of facial seborrhea and acne with botulinum neurotoxin type A.Nark-Kyoung RhoYoung-Chun GilMDPI AGarticleacetylcholineacne vulgarisbotulinum toxinscholinergic receptorsnon-neuronal cholinergic systemoily skinMedicineRENToxins, Vol 13, Iss 817, p 817 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acetylcholine acne vulgaris botulinum toxins cholinergic receptors non-neuronal cholinergic system oily skin Medicine R
spellingShingle	acetylcholine acne vulgaris botulinum toxins cholinergic receptors non-neuronal cholinergic system oily skin Medicine R Nark-Kyoung Rho Young-Chun Gil Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism
description	Intradermal injection of botulinum neurotoxin is a frequently performed procedure in aesthetic dermatology to improve facial skin tone, texture, fine wrinkles, and enlarged pores. In practice, botulinum neurotoxin type A is also used to reduce skin oiliness of the face. There is increasing evidence that acetylcholine plays specific roles in sebum production, suggesting that botulinum neurotoxin type A may reduce sebum production by interfering with cholinergic transmission between sebaceous glands and autonomic nerve terminals. Botulinum neurotoxins can also inhibit several pathogenetic components of acne development, suggesting that botulinum neurotoxins can be used as a safe and effective treatment modality for acne and other skin disorders related to overactivity of sebaceous glands. This review aims to explore the current evidence behind the treatment of facial seborrhea and acne with botulinum neurotoxin type A.
format	article
author	Nark-Kyoung Rho Young-Chun Gil
author_facet	Nark-Kyoung Rho Young-Chun Gil
author_sort	Nark-Kyoung Rho
title	Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism
title_short	Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism
title_full	Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism
title_fullStr	Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism
title_full_unstemmed	Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism
title_sort	botulinum neurotoxin type a in the treatment of facial seborrhea and acne: evidence and a proposed mechanism
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ba4e63199f4f4487a4cee440c8214863
work_keys_str_mv	AT narkkyoungrho botulinumneurotoxintypeainthetreatmentoffacialseborrheaandacneevidenceandaproposedmechanism AT youngchungil botulinumneurotoxintypeainthetreatmentoffacialseborrheaandacneevidenceandaproposedmechanism
_version_	1718410238934122496

Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism

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