Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease

Abstract Interstitial lung disease (ILD) is the most common lung manifestation in patients with Sjögren syndrome (SJS) and is associated with poor outcomes. This study aimed to investigate the long-term clinical course and prognostic factors in patients with SJS-ILD. Clinical data and high-resolutio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yun Jae Kim, Jooae Choe, Ho Jeong Kim, Jin Woo Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba4f33c0695a495788d04471b2377d4a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ba4f33c0695a495788d04471b2377d4a
record_format	dspace
spelling	oai:doaj.org-article:ba4f33c0695a495788d04471b2377d4a2021-12-02T17:24:00ZLong-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease10.1038/s41598-021-92024-22045-2322https://doaj.org/article/ba4f33c0695a495788d04471b2377d4a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92024-2https://doaj.org/toc/2045-2322Abstract Interstitial lung disease (ILD) is the most common lung manifestation in patients with Sjögren syndrome (SJS) and is associated with poor outcomes. This study aimed to investigate the long-term clinical course and prognostic factors in patients with SJS-ILD. Clinical data and high-resolution computed tomography (HRCT) images of 62 patients with primary SJS-ILD were retrospectively analyzed (biopsy-proven cases, n = 16). The mean patient age was 59.8 years; 83.9% of the patients were females, and 38.7% showed a usual interstitial pneumonia (UIP) pattern on HRCT. The median follow-up period was 61.5 months. During follow-up, 15 patients (24.2%) died, 7 (11.3%) experienced acute exacerbation (AE), and 27 (43.5%) progressed. The 1-, 3- and 5-year survival rates were 93.5%, 85.8%, and 81.1%, respectively. Age (hazard ratio [HR]: 1.158, P = 0.003), C-reactive protein (CRP) level (HR: 1.212, P = 0.045), FVC (HR: 0.902, P = 0.005), and a UIP pattern on HRCT (HR: 4.580, P = 0.029) were significant prognostic factors in multivariable Cox analysis. In conclusion, death, AE, and ILD progression occurred in 25%, 10%, and 50% of the patients with SJS-ILD, respectively. Older age, higher CRP level, lower FVC, and a UIP pattern on HRCT indicated poor prognosis.Yun Jae KimJooae ChoeHo Jeong KimJin Woo SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Jae Kim Jooae Choe Ho Jeong Kim Jin Woo Song Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease
description	Abstract Interstitial lung disease (ILD) is the most common lung manifestation in patients with Sjögren syndrome (SJS) and is associated with poor outcomes. This study aimed to investigate the long-term clinical course and prognostic factors in patients with SJS-ILD. Clinical data and high-resolution computed tomography (HRCT) images of 62 patients with primary SJS-ILD were retrospectively analyzed (biopsy-proven cases, n = 16). The mean patient age was 59.8 years; 83.9% of the patients were females, and 38.7% showed a usual interstitial pneumonia (UIP) pattern on HRCT. The median follow-up period was 61.5 months. During follow-up, 15 patients (24.2%) died, 7 (11.3%) experienced acute exacerbation (AE), and 27 (43.5%) progressed. The 1-, 3- and 5-year survival rates were 93.5%, 85.8%, and 81.1%, respectively. Age (hazard ratio [HR]: 1.158, P = 0.003), C-reactive protein (CRP) level (HR: 1.212, P = 0.045), FVC (HR: 0.902, P = 0.005), and a UIP pattern on HRCT (HR: 4.580, P = 0.029) were significant prognostic factors in multivariable Cox analysis. In conclusion, death, AE, and ILD progression occurred in 25%, 10%, and 50% of the patients with SJS-ILD, respectively. Older age, higher CRP level, lower FVC, and a UIP pattern on HRCT indicated poor prognosis.
format	article
author	Yun Jae Kim Jooae Choe Ho Jeong Kim Jin Woo Song
author_facet	Yun Jae Kim Jooae Choe Ho Jeong Kim Jin Woo Song
author_sort	Yun Jae Kim
title	Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease
title_short	Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease
title_full	Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease
title_fullStr	Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease
title_full_unstemmed	Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease
title_sort	long-term clinical course and outcome in patients with primary sjögren syndrome-associated interstitial lung disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba4f33c0695a495788d04471b2377d4a
work_keys_str_mv	AT yunjaekim longtermclinicalcourseandoutcomeinpatientswithprimarysjogrensyndromeassociatedinterstitiallungdisease AT jooaechoe longtermclinicalcourseandoutcomeinpatientswithprimarysjogrensyndromeassociatedinterstitiallungdisease AT hojeongkim longtermclinicalcourseandoutcomeinpatientswithprimarysjogrensyndromeassociatedinterstitiallungdisease AT jinwoosong longtermclinicalcourseandoutcomeinpatientswithprimarysjogrensyndromeassociatedinterstitiallungdisease
_version_	1718380991771312128

Long-term clinical course and outcome in patients with primary Sjögren syndrome-associated interstitial lung disease

Ejemplares similares