Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.

Previous PET and MRI studies have indicated that the degree to which pathology translates into clinical symptoms is strongly dependent on sex with women more likely to express pathology as a diagnosis of AD, whereas men are more resistant to clinical symptoms in the face of the same degree of pathol...

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Autores principales:	Laurence O'Dwyer, Franck Lamberton, Arun L W Bokde, Michael Ewers, Yetunde O Faluyi, Colby Tanner, Bernard Mazoyer, Desmond O'Neill, Máiréad Bartley, Rónán Collins, Tara Coughlan, David Prvulovic, Harald Hampel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba548ac9ca3a4e6d908c2a73f7215a10
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spelling	oai:doaj.org-article:ba548ac9ca3a4e6d908c2a73f7215a102021-11-18T07:13:35ZSexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.1932-620310.1371/journal.pone.0037021https://doaj.org/article/ba548ac9ca3a4e6d908c2a73f7215a102012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22768288/?tool=EBIhttps://doaj.org/toc/1932-6203Previous PET and MRI studies have indicated that the degree to which pathology translates into clinical symptoms is strongly dependent on sex with women more likely to express pathology as a diagnosis of AD, whereas men are more resistant to clinical symptoms in the face of the same degree of pathology. Here we use DTI to investigate the difference between male and female white matter tracts in healthy older participants (24 women, 16 men) and participants with mild cognitive impairment (21 women, 12 men). Differences between control and MCI participants were found in fractional anisotropy (FA), radial diffusion (DR), axial diffusion (DA) and mean diffusion (MD). A significant main effect of sex was also reported for FA, MD and DR indices, with male control and male MCI participants having significantly more microstructural damage than their female counterparts. There was no sex by diagnosis interaction. Male MCIs also had significantly less normalised grey matter (GM) volume than female MCIs. However, in terms of absolute brain volume, male controls had significantly more brain volume than female controls. Normalised GM and WM volumes were found to decrease significantly with age with no age by sex interaction. Overall, these data suggest that the same degree of cognitive impairment is associated with greater structural damage in men compared with women.Laurence O'DwyerFranck LambertonArun L W BokdeMichael EwersYetunde O FaluyiColby TannerBernard MazoyerDesmond O'NeillMáiréad BartleyRónán CollinsTara CoughlanDavid PrvulovicHarald HampelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e37021 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laurence O'Dwyer Franck Lamberton Arun L W Bokde Michael Ewers Yetunde O Faluyi Colby Tanner Bernard Mazoyer Desmond O'Neill Máiréad Bartley Rónán Collins Tara Coughlan David Prvulovic Harald Hampel Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.
description	Previous PET and MRI studies have indicated that the degree to which pathology translates into clinical symptoms is strongly dependent on sex with women more likely to express pathology as a diagnosis of AD, whereas men are more resistant to clinical symptoms in the face of the same degree of pathology. Here we use DTI to investigate the difference between male and female white matter tracts in healthy older participants (24 women, 16 men) and participants with mild cognitive impairment (21 women, 12 men). Differences between control and MCI participants were found in fractional anisotropy (FA), radial diffusion (DR), axial diffusion (DA) and mean diffusion (MD). A significant main effect of sex was also reported for FA, MD and DR indices, with male control and male MCI participants having significantly more microstructural damage than their female counterparts. There was no sex by diagnosis interaction. Male MCIs also had significantly less normalised grey matter (GM) volume than female MCIs. However, in terms of absolute brain volume, male controls had significantly more brain volume than female controls. Normalised GM and WM volumes were found to decrease significantly with age with no age by sex interaction. Overall, these data suggest that the same degree of cognitive impairment is associated with greater structural damage in men compared with women.
format	article
author	Laurence O'Dwyer Franck Lamberton Arun L W Bokde Michael Ewers Yetunde O Faluyi Colby Tanner Bernard Mazoyer Desmond O'Neill Máiréad Bartley Rónán Collins Tara Coughlan David Prvulovic Harald Hampel
author_facet	Laurence O'Dwyer Franck Lamberton Arun L W Bokde Michael Ewers Yetunde O Faluyi Colby Tanner Bernard Mazoyer Desmond O'Neill Máiréad Bartley Rónán Collins Tara Coughlan David Prvulovic Harald Hampel
author_sort	Laurence O'Dwyer
title	Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.
title_short	Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.
title_full	Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.
title_fullStr	Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.
title_full_unstemmed	Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.
title_sort	sexual dimorphism in healthy aging and mild cognitive impairment: a dti study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ba548ac9ca3a4e6d908c2a73f7215a10
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Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.

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