Antibacterial and antibiofouling clay nanotube–silicone composite

Antibacterial and antibiofouling clay nanotube–silicone composite

CJ Boyer,1 J Ambrose Jr,2 S Das,1 A Humayun,1 D Chappidi,1 R Giorno,3 DK Mills2,3 1Molecular Science and Nanotechnology, College of Engineering & Science, Louisiana Tech University, Ruston, LA, USA; 2Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Rus...

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Autores principales: Boyer CJ, Ambrose J Jr, Das S, Humayun A, Chappidi D, Giorno R, Mills DK
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
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Medical technology
R855-855.5
Acceso en línea:https://doaj.org/article/ba550da235d54280b0f57b37b931555c
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spelling oai:doaj.org-article:ba550da235d54280b0f57b37b931555c2021-12-02T11:07:32ZAntibacterial and antibiofouling clay nanotube–silicone composite1179-1470https://doaj.org/article/ba550da235d54280b0f57b37b931555c2018-04-01T00:00:00Zhttps://www.dovepress.com/antibacterial-and-antibiofouling-clay-nanotube-silicone-composite-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470CJ Boyer,1 J Ambrose Jr,2 S Das,1 A Humayun,1 D Chappidi,1 R Giorno,3 DK Mills2,3 1Molecular Science and Nanotechnology, College of Engineering & Science, Louisiana Tech University, Ruston, LA, USA; 2Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA, USA; 3School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA Introduction: Invasive medical devices are used in treating millions of patients each day. Bacterial adherence to their surface is an early step in biofilm formation that may lead to infection, health complications, longer hospital stays, and death. Prevention of bacterial adherence and biofilm development continues to be a major healthcare challenge. Accordingly, there is a pressing need to improve the anti-microbial properties of medical devices. Materials and Methods: Polydimethylsiloxane (PDMS) was doped with halloysite nanotubes (HNTs), and the PDMS-HNT composite surfaces were coated with PDMS-b-polyethylene oxide (PEO) and antibacterials. The composite material properties were examined using SEM, energy dispersive spectroscopy, water contact angle measurements, tensile testing, UV-Vis spectroscopy, and thermal gravimetric analysis. The antibacterial potential of the PDMS-HNT composites was compared to commercial urinary catheters using cultures of E. coli and S. aureus. Fibrinogen adsorption studies were also performed on the PDMS-HNT-PEO composites. Results: HNT addition increased drug load during solvent swelling without reducing material strength. The hydrophilic properties provided by PEO were maintained after HNT addition, and the composites displayed protein-repelling properties. Additionally, composites showed superiority over commercial catheters at inhibiting bacterial growth. Conclusion: PDMS-HNT composites showed superiority regarding their efficacy at inhibiting bacterial growth, in comparison to commercial antibacterial catheters. Our data suggest that PDMS-HNT composites have potential as a coating material for anti-bacterial invasive devices and in the prevention of institutional-acquired infections. Keywords: antibacterials, halloysite, medical devices, nanocomposites, PDMSBoyer CJAmbrose J JrDas SHumayun AChappidi DGiorno RMills DKDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol Volume 11, Pp 123-137 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medical technology
R855-855.5
spellingShingle Medical technology
R855-855.5
Boyer CJ
Ambrose J Jr
Das S
Humayun A
Chappidi D
Giorno R
Mills DK
Antibacterial and antibiofouling clay nanotube–silicone composite
description CJ Boyer,1 J Ambrose Jr,2 S Das,1 A Humayun,1 D Chappidi,1 R Giorno,3 DK Mills2,3 1Molecular Science and Nanotechnology, College of Engineering & Science, Louisiana Tech University, Ruston, LA, USA; 2Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA, USA; 3School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA Introduction: Invasive medical devices are used in treating millions of patients each day. Bacterial adherence to their surface is an early step in biofilm formation that may lead to infection, health complications, longer hospital stays, and death. Prevention of bacterial adherence and biofilm development continues to be a major healthcare challenge. Accordingly, there is a pressing need to improve the anti-microbial properties of medical devices. Materials and Methods: Polydimethylsiloxane (PDMS) was doped with halloysite nanotubes (HNTs), and the PDMS-HNT composite surfaces were coated with PDMS-b-polyethylene oxide (PEO) and antibacterials. The composite material properties were examined using SEM, energy dispersive spectroscopy, water contact angle measurements, tensile testing, UV-Vis spectroscopy, and thermal gravimetric analysis. The antibacterial potential of the PDMS-HNT composites was compared to commercial urinary catheters using cultures of E. coli and S. aureus. Fibrinogen adsorption studies were also performed on the PDMS-HNT-PEO composites. Results: HNT addition increased drug load during solvent swelling without reducing material strength. The hydrophilic properties provided by PEO were maintained after HNT addition, and the composites displayed protein-repelling properties. Additionally, composites showed superiority over commercial catheters at inhibiting bacterial growth. Conclusion: PDMS-HNT composites showed superiority regarding their efficacy at inhibiting bacterial growth, in comparison to commercial antibacterial catheters. Our data suggest that PDMS-HNT composites have potential as a coating material for anti-bacterial invasive devices and in the prevention of institutional-acquired infections. Keywords: antibacterials, halloysite, medical devices, nanocomposites, PDMS
format article
author Boyer CJ
Ambrose J Jr
Das S
Humayun A
Chappidi D
Giorno R
Mills DK
author_facet Boyer CJ
Ambrose J Jr
Das S
Humayun A
Chappidi D
Giorno R
Mills DK
author_sort Boyer CJ
title Antibacterial and antibiofouling clay nanotube–silicone composite
title_short Antibacterial and antibiofouling clay nanotube–silicone composite
title_full Antibacterial and antibiofouling clay nanotube–silicone composite
title_fullStr Antibacterial and antibiofouling clay nanotube–silicone composite
title_full_unstemmed Antibacterial and antibiofouling clay nanotube–silicone composite
title_sort antibacterial and antibiofouling clay nanotube–silicone composite
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/ba550da235d54280b0f57b37b931555c
work_keys_str_mv AT boyercj antibacterialandantibiofoulingclaynanotubendashsiliconecomposite
AT ambrosejjr antibacterialandantibiofoulingclaynanotubendashsiliconecomposite
AT dass antibacterialandantibiofoulingclaynanotubendashsiliconecomposite
AT humayuna antibacterialandantibiofoulingclaynanotubendashsiliconecomposite
AT chappidid antibacterialandantibiofoulingclaynanotubendashsiliconecomposite
AT giornor antibacterialandantibiofoulingclaynanotubendashsiliconecomposite
AT millsdk antibacterialandantibiofoulingclaynanotubendashsiliconecomposite
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