Resting state functional connectivity in patients with chronic hallucinations.

Auditory verbal hallucinations (AVH) are not only among the most common but also one of the most distressing symptoms of schizophrenia. Despite elaborate research, the underlying brain mechanisms are as yet elusive. Functional MRI studies have associated the experience of AVH with activation of bila...

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Autores principales:	Iris E Sommer, Mareike Clos, Anne Lotte Meijering, Kelly M J Diederen, Simon B Eickhoff
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba5e6c9812fc4abcbae55920145ab46e
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spelling	oai:doaj.org-article:ba5e6c9812fc4abcbae55920145ab46e2021-11-18T07:06:28ZResting state functional connectivity in patients with chronic hallucinations.1932-620310.1371/journal.pone.0043516https://doaj.org/article/ba5e6c9812fc4abcbae55920145ab46e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22970130/?tool=EBIhttps://doaj.org/toc/1932-6203Auditory verbal hallucinations (AVH) are not only among the most common but also one of the most distressing symptoms of schizophrenia. Despite elaborate research, the underlying brain mechanisms are as yet elusive. Functional MRI studies have associated the experience of AVH with activation of bilateral language-related areas, in particular the right inferior frontal gyrus (rIFG) and the left superior temporal gyrus (lSTG). While these findings helped to understand the neural underpinnings of hearing voices, they provide little information about possible brain mechanisms that predispose a person to experience AVH, i.e. the traits to hallucinate. In this study, we compared resting state connectivity between 49 psychotic patients with chronic AVH and 49 matched controls using the rIFG and the lSTG as seed regions, to identify functional brain systems underlying the predisposition to hallucinate. The right parahippocampal gyrus showed increased connectivity with the rIFG in patients as compared to controls. Reduced connectivity with the rIFG in patients was found for the right dorsolateral prefrontal cortex. Reduced connectivity with the lSTG in patients was identified in the left frontal operculum as well as the parietal opercular area. Connectivity between the lSTG and the left hippocampus was also reduced in patients and showed a negative correlation with the severity of hallucinations. Concluding, we found aberrant connectivity between the seed regions and medial temporal lobe structures which have a prominent role in memory retrieval. Moreover, we found decreased connectivity between language-related areas, indicating aberrant integration in this system potentially including corollary discharge mechanisms.Iris E SommerMareike ClosAnne Lotte MeijeringKelly M J DiederenSimon B EickhoffPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e43516 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iris E Sommer Mareike Clos Anne Lotte Meijering Kelly M J Diederen Simon B Eickhoff Resting state functional connectivity in patients with chronic hallucinations.
description	Auditory verbal hallucinations (AVH) are not only among the most common but also one of the most distressing symptoms of schizophrenia. Despite elaborate research, the underlying brain mechanisms are as yet elusive. Functional MRI studies have associated the experience of AVH with activation of bilateral language-related areas, in particular the right inferior frontal gyrus (rIFG) and the left superior temporal gyrus (lSTG). While these findings helped to understand the neural underpinnings of hearing voices, they provide little information about possible brain mechanisms that predispose a person to experience AVH, i.e. the traits to hallucinate. In this study, we compared resting state connectivity between 49 psychotic patients with chronic AVH and 49 matched controls using the rIFG and the lSTG as seed regions, to identify functional brain systems underlying the predisposition to hallucinate. The right parahippocampal gyrus showed increased connectivity with the rIFG in patients as compared to controls. Reduced connectivity with the rIFG in patients was found for the right dorsolateral prefrontal cortex. Reduced connectivity with the lSTG in patients was identified in the left frontal operculum as well as the parietal opercular area. Connectivity between the lSTG and the left hippocampus was also reduced in patients and showed a negative correlation with the severity of hallucinations. Concluding, we found aberrant connectivity between the seed regions and medial temporal lobe structures which have a prominent role in memory retrieval. Moreover, we found decreased connectivity between language-related areas, indicating aberrant integration in this system potentially including corollary discharge mechanisms.
format	article
author	Iris E Sommer Mareike Clos Anne Lotte Meijering Kelly M J Diederen Simon B Eickhoff
author_facet	Iris E Sommer Mareike Clos Anne Lotte Meijering Kelly M J Diederen Simon B Eickhoff
author_sort	Iris E Sommer
title	Resting state functional connectivity in patients with chronic hallucinations.
title_short	Resting state functional connectivity in patients with chronic hallucinations.
title_full	Resting state functional connectivity in patients with chronic hallucinations.
title_fullStr	Resting state functional connectivity in patients with chronic hallucinations.
title_full_unstemmed	Resting state functional connectivity in patients with chronic hallucinations.
title_sort	resting state functional connectivity in patients with chronic hallucinations.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ba5e6c9812fc4abcbae55920145ab46e
work_keys_str_mv	AT irisesommer restingstatefunctionalconnectivityinpatientswithchronichallucinations AT mareikeclos restingstatefunctionalconnectivityinpatientswithchronichallucinations AT annelottemeijering restingstatefunctionalconnectivityinpatientswithchronichallucinations AT kellymjdiederen restingstatefunctionalconnectivityinpatientswithchronichallucinations AT simonbeickhoff restingstatefunctionalconnectivityinpatientswithchronichallucinations
_version_	1718423938042691584

Resting state functional connectivity in patients with chronic hallucinations.

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