Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome

Salvatore Putignano, Pietro Gareri, Alberto Castagna, Giuliano Cerqua, Pasquale Cervera, Antonino Maria Cotroneo, Francesco Fiorillo, Roberto Grella, Roberto Lacava, Antonio Maddonni, Saverio Marino, Alice Pluderi, Daria Putignano, Filomena RoccaAssociazione Geriatri Extraospedalieri – Ger...

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Autores principales:	Putignano S, Gareri P, Castagna A, Cerqua G, Cervera P, Cotroneo AM, Fiorillo F, Grella R, Lacava R, Maddonni A, Marino S, Pluderi A, Putignano D, Rocca F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Geriatric syndrome citicoline Alzheimer's disease cerebrovascular disease comorbidities Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ba5e84386dee4c568d8afbc75b74505f
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spelling	oai:doaj.org-article:ba5e84386dee4c568d8afbc75b74505f2021-12-02T04:07:44ZRetrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome1178-1998https://doaj.org/article/ba5e84386dee4c568d8afbc75b74505f2012-05-01T00:00:00Zhttps://www.dovepress.com/retrospective-and-observational-study-to-assess-the-efficacy-of-citico-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Salvatore Putignano, Pietro Gareri, Alberto Castagna, Giuliano Cerqua, Pasquale Cervera, Antonino Maria Cotroneo, Francesco Fiorillo, Roberto Grella, Roberto Lacava, Antonio Maddonni, Saverio Marino, Alice Pluderi, Daria Putignano, Filomena RoccaAssociazione Geriatri Extraospedalieri – Geriatria Italiana Territoriale, Tenore 17, Naples, ItalyAbstract: A significant percentage of elderly subjects (50%–80%) suffering from sub-acute ischemic cerebrovascular disease, with or without moderate or severe cognitive memory decline and with or without associated behavioral and psychological symptoms, shows a complex syndrome. This syndrome is related to the progressive impairment of health conditions and/or stressing events (ie, hospitalization), characterized by confusion and/or stupor, which are consequently difficult to manage and require a great deal of care. Geriatric patients often suffer from multiple chronic illnesses, may take numerous medications daily, exhibit clinical instability, and may experience worsening of medical conditions following cerebral ischemic events and thus have an increased risk of disability and mortality. There are several studies in literature which demonstrate the efficacy of citicoline, thanks to its neuroprotective function, for the recovery and in postischemic cerebral rehabilitation. It has been shown that, even soon after an ischemic stroke, administration of oral citicoline (500–4000 mg/day) improves the general conditions evaluated with the Rankin scale and the National Institute of Health Stroke Scale 12. In particular, it has been shown that the CDP-choline improves the cognitive and mental performance in Alzheimer's dementia and vascular dementia. We have evaluated the administration of citicoline in geriatric patients following a protocol of intravenous study on improvement of individual performances.Keywords: geriatric syndrome, citicoline, Alzheimer's disease, cerebrovascular disease, comorbiditiesCorrigendum for this paper has been publishedPutignano SGareri PCastagna ACerqua GCervera PCotroneo AMFiorillo FGrella RLacava RMaddonni AMarino SPluderi APutignano DRocca FDove Medical PressarticleGeriatric syndromeciticolineAlzheimer's diseasecerebrovascular diseasecomorbiditiesGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 7, Pp 113-118 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatric syndrome citicoline Alzheimer's disease cerebrovascular disease comorbidities Geriatrics RC952-954.6
spellingShingle	Geriatric syndrome citicoline Alzheimer's disease cerebrovascular disease comorbidities Geriatrics RC952-954.6 Putignano S Gareri P Castagna A Cerqua G Cervera P Cotroneo AM Fiorillo F Grella R Lacava R Maddonni A Marino S Pluderi A Putignano D Rocca F Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
description	Salvatore Putignano, Pietro Gareri, Alberto Castagna, Giuliano Cerqua, Pasquale Cervera, Antonino Maria Cotroneo, Francesco Fiorillo, Roberto Grella, Roberto Lacava, Antonio Maddonni, Saverio Marino, Alice Pluderi, Daria Putignano, Filomena RoccaAssociazione Geriatri Extraospedalieri – Geriatria Italiana Territoriale, Tenore 17, Naples, ItalyAbstract: A significant percentage of elderly subjects (50%–80%) suffering from sub-acute ischemic cerebrovascular disease, with or without moderate or severe cognitive memory decline and with or without associated behavioral and psychological symptoms, shows a complex syndrome. This syndrome is related to the progressive impairment of health conditions and/or stressing events (ie, hospitalization), characterized by confusion and/or stupor, which are consequently difficult to manage and require a great deal of care. Geriatric patients often suffer from multiple chronic illnesses, may take numerous medications daily, exhibit clinical instability, and may experience worsening of medical conditions following cerebral ischemic events and thus have an increased risk of disability and mortality. There are several studies in literature which demonstrate the efficacy of citicoline, thanks to its neuroprotective function, for the recovery and in postischemic cerebral rehabilitation. It has been shown that, even soon after an ischemic stroke, administration of oral citicoline (500–4000 mg/day) improves the general conditions evaluated with the Rankin scale and the National Institute of Health Stroke Scale 12. In particular, it has been shown that the CDP-choline improves the cognitive and mental performance in Alzheimer's dementia and vascular dementia. We have evaluated the administration of citicoline in geriatric patients following a protocol of intravenous study on improvement of individual performances.Keywords: geriatric syndrome, citicoline, Alzheimer's disease, cerebrovascular disease, comorbiditiesCorrigendum for this paper has been published
format	article
author	Putignano S Gareri P Castagna A Cerqua G Cervera P Cotroneo AM Fiorillo F Grella R Lacava R Maddonni A Marino S Pluderi A Putignano D Rocca F
author_facet	Putignano S Gareri P Castagna A Cerqua G Cervera P Cotroneo AM Fiorillo F Grella R Lacava R Maddonni A Marino S Pluderi A Putignano D Rocca F
author_sort	Putignano S
title	Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
title_short	Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
title_full	Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
title_fullStr	Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
title_full_unstemmed	Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
title_sort	retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/ba5e84386dee4c568d8afbc75b74505f
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Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome

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