Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients

Abstract The prognosis of patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is a research hotspot. This study aimed to incorporate important factors obtained from SEER database to construct and validate a nomogram for predicting the cancer-specific survival (CSS)...

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Autores principales:	Kang Liu, Gaobo Huang, Pengkang Chang, Wei Zhang, Tao Li, Zhijun Dai, Yi Lv
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba5f92017be04831871927fdc5005ff1
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spelling	oai:doaj.org-article:ba5f92017be04831871927fdc5005ff12021-12-02T16:09:10ZConstruction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients10.1038/s41598-020-78545-22045-2322https://doaj.org/article/ba5f92017be04831871927fdc5005ff12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78545-2https://doaj.org/toc/2045-2322Abstract The prognosis of patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is a research hotspot. This study aimed to incorporate important factors obtained from SEER database to construct and validate a nomogram for predicting the cancer-specific survival (CSS) of patients with HCC and ICC. We obtained patient data from SEER database. The nomogram was constructed base on six prognostic factors for predicting CSS rates in HCC patients. The nomogram was validated by concordance index (C-index), the receiver operating characteristic (ROC) curve and calibration curves. A total of 3227 patients diagnosed with HCC (3038) and ICC (189) between 2010 and 2015 were included in this study. The C-index of the nomogram for HCC patients was 0.790 in the training cohort and 0.806 in the validation cohort. The 3- and 5-year AUCs were 0.811 and 0.793 in the training cohort. The calibration plots indicated that there was good agreement between the actual observations and predictions. In conclusion, we constructed and validated a nomogram for predicting the 3- and 5-year CSS in HCC patients. We have confirmed the precise calibration and excellent discrimination power of our nomogram.Kang LiuGaobo HuangPengkang ChangWei ZhangTao LiZhijun DaiYi LvNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kang Liu Gaobo Huang Pengkang Chang Wei Zhang Tao Li Zhijun Dai Yi Lv Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients
description	Abstract The prognosis of patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is a research hotspot. This study aimed to incorporate important factors obtained from SEER database to construct and validate a nomogram for predicting the cancer-specific survival (CSS) of patients with HCC and ICC. We obtained patient data from SEER database. The nomogram was constructed base on six prognostic factors for predicting CSS rates in HCC patients. The nomogram was validated by concordance index (C-index), the receiver operating characteristic (ROC) curve and calibration curves. A total of 3227 patients diagnosed with HCC (3038) and ICC (189) between 2010 and 2015 were included in this study. The C-index of the nomogram for HCC patients was 0.790 in the training cohort and 0.806 in the validation cohort. The 3- and 5-year AUCs were 0.811 and 0.793 in the training cohort. The calibration plots indicated that there was good agreement between the actual observations and predictions. In conclusion, we constructed and validated a nomogram for predicting the 3- and 5-year CSS in HCC patients. We have confirmed the precise calibration and excellent discrimination power of our nomogram.
format	article
author	Kang Liu Gaobo Huang Pengkang Chang Wei Zhang Tao Li Zhijun Dai Yi Lv
author_facet	Kang Liu Gaobo Huang Pengkang Chang Wei Zhang Tao Li Zhijun Dai Yi Lv
author_sort	Kang Liu
title	Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients
title_short	Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients
title_full	Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients
title_fullStr	Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients
title_full_unstemmed	Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients
title_sort	construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ba5f92017be04831871927fdc5005ff1
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Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients

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