Sex hormones drive changes in lipoprotein metabolism

Summary: Women have a reduced cardiovascular disease (CVD) risk compared with men, which could be partially driven by sex hormones influencing lipid levels post puberty. The interrelationship between sex hormones and lipids was explored in pre-pubertal children, young post-pubertal cis-men/women, an...

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Autores principales:	George A. Robinson, Junjie Peng, Hannah Peckham, Anna Radziszewska, Gary Butler, Ines Pineda-Torra, Elizabeth C. Jury, Coziana Ciurtin
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences Biochemistry Metabolomics Science Q
Acceso en línea:	https://doaj.org/article/ba63a83455f646859af1394b4918fb68
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spelling	oai:doaj.org-article:ba63a83455f646859af1394b4918fb682021-11-20T05:08:57ZSex hormones drive changes in lipoprotein metabolism2589-004210.1016/j.isci.2021.103257https://doaj.org/article/ba63a83455f646859af1394b4918fb682021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012268https://doaj.org/toc/2589-0042Summary: Women have a reduced cardiovascular disease (CVD) risk compared with men, which could be partially driven by sex hormones influencing lipid levels post puberty. The interrelationship between sex hormones and lipids was explored in pre-pubertal children, young post-pubertal cis-men/women, and transgender individuals on cross-sex-hormone treatment (trans-men/women) using serum metabolomics assessing 149 lipids. High-density lipoproteins (HDL, typically atheroprotective) were significantly increased and very-low- and low-density lipoproteins (typically atherogenic) were significantly decreased in post-pubertal cis-women compared with cis-men. These differences were not observed pre-puberty and were induced appropriately by cross-sex-hormone treatment in transgender individuals, supporting that sex hormones regulate lipid metabolism in vivo. Only atheroprotective apolipoprotein (Apo)A1 expressing lipoproteins (HDL) were differentially expressed between all hormonally unique comparisons. Thus, estradiol drives a typically atheroprotective lipid profile through upregulation of HDL/ApoA1, which could contribute to the sexual dimorphism observed in CVD risk post puberty. Together, this could inform sex-specific therapeutic strategies for CVD management.George A. RobinsonJunjie PengHannah PeckhamAnna RadziszewskaGary ButlerInes Pineda-TorraElizabeth C. JuryCoziana CiurtinElsevierarticleBiological sciencesBiochemistryMetabolomicsScienceQENiScience, Vol 24, Iss 11, Pp 103257- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences Biochemistry Metabolomics Science Q
spellingShingle	Biological sciences Biochemistry Metabolomics Science Q George A. Robinson Junjie Peng Hannah Peckham Anna Radziszewska Gary Butler Ines Pineda-Torra Elizabeth C. Jury Coziana Ciurtin Sex hormones drive changes in lipoprotein metabolism
description	Summary: Women have a reduced cardiovascular disease (CVD) risk compared with men, which could be partially driven by sex hormones influencing lipid levels post puberty. The interrelationship between sex hormones and lipids was explored in pre-pubertal children, young post-pubertal cis-men/women, and transgender individuals on cross-sex-hormone treatment (trans-men/women) using serum metabolomics assessing 149 lipids. High-density lipoproteins (HDL, typically atheroprotective) were significantly increased and very-low- and low-density lipoproteins (typically atherogenic) were significantly decreased in post-pubertal cis-women compared with cis-men. These differences were not observed pre-puberty and were induced appropriately by cross-sex-hormone treatment in transgender individuals, supporting that sex hormones regulate lipid metabolism in vivo. Only atheroprotective apolipoprotein (Apo)A1 expressing lipoproteins (HDL) were differentially expressed between all hormonally unique comparisons. Thus, estradiol drives a typically atheroprotective lipid profile through upregulation of HDL/ApoA1, which could contribute to the sexual dimorphism observed in CVD risk post puberty. Together, this could inform sex-specific therapeutic strategies for CVD management.
format	article
author	George A. Robinson Junjie Peng Hannah Peckham Anna Radziszewska Gary Butler Ines Pineda-Torra Elizabeth C. Jury Coziana Ciurtin
author_facet	George A. Robinson Junjie Peng Hannah Peckham Anna Radziszewska Gary Butler Ines Pineda-Torra Elizabeth C. Jury Coziana Ciurtin
author_sort	George A. Robinson
title	Sex hormones drive changes in lipoprotein metabolism
title_short	Sex hormones drive changes in lipoprotein metabolism
title_full	Sex hormones drive changes in lipoprotein metabolism
title_fullStr	Sex hormones drive changes in lipoprotein metabolism
title_full_unstemmed	Sex hormones drive changes in lipoprotein metabolism
title_sort	sex hormones drive changes in lipoprotein metabolism
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ba63a83455f646859af1394b4918fb68
work_keys_str_mv	AT georgearobinson sexhormonesdrivechangesinlipoproteinmetabolism AT junjiepeng sexhormonesdrivechangesinlipoproteinmetabolism AT hannahpeckham sexhormonesdrivechangesinlipoproteinmetabolism AT annaradziszewska sexhormonesdrivechangesinlipoproteinmetabolism AT garybutler sexhormonesdrivechangesinlipoproteinmetabolism AT inespinedatorra sexhormonesdrivechangesinlipoproteinmetabolism AT elizabethcjury sexhormonesdrivechangesinlipoproteinmetabolism AT cozianaciurtin sexhormonesdrivechangesinlipoproteinmetabolism
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Sex hormones drive changes in lipoprotein metabolism

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