Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis

During clathrin mediated endocytosis (CME), membrane scission is achieved by the concerted action of dynamin and its interacting partners such as amphiphysins. Here authors show that efficient recruitment and function of dynamin requires simultaneous binding of multiple amphiphysin SH3 domains.

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Autores principales:	Morgane Rosendale, Thi Nhu Ngoc Van, Dolors Grillo-Bosch, Silvia Sposini, Léa Claverie, Isabel Gauthereau, Stéphane Claverol, Daniel Choquet, Matthieu Sainlos, David Perrais
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba6e9aee54e54df3b3011ac958eab9c6
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spelling	oai:doaj.org-article:ba6e9aee54e54df3b3011ac958eab9c62021-12-02T14:39:16ZFunctional recruitment of dynamin requires multimeric interactions for efficient endocytosis10.1038/s41467-019-12434-92041-1723https://doaj.org/article/ba6e9aee54e54df3b3011ac958eab9c62019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12434-9https://doaj.org/toc/2041-1723During clathrin mediated endocytosis (CME), membrane scission is achieved by the concerted action of dynamin and its interacting partners such as amphiphysins. Here authors show that efficient recruitment and function of dynamin requires simultaneous binding of multiple amphiphysin SH3 domains.Morgane RosendaleThi Nhu Ngoc VanDolors Grillo-BoschSilvia SposiniLéa ClaverieIsabel GauthereauStéphane ClaverolDaniel ChoquetMatthieu SainlosDavid PerraisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Morgane Rosendale Thi Nhu Ngoc Van Dolors Grillo-Bosch Silvia Sposini Léa Claverie Isabel Gauthereau Stéphane Claverol Daniel Choquet Matthieu Sainlos David Perrais Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
description	During clathrin mediated endocytosis (CME), membrane scission is achieved by the concerted action of dynamin and its interacting partners such as amphiphysins. Here authors show that efficient recruitment and function of dynamin requires simultaneous binding of multiple amphiphysin SH3 domains.
format	article
author	Morgane Rosendale Thi Nhu Ngoc Van Dolors Grillo-Bosch Silvia Sposini Léa Claverie Isabel Gauthereau Stéphane Claverol Daniel Choquet Matthieu Sainlos David Perrais
author_facet	Morgane Rosendale Thi Nhu Ngoc Van Dolors Grillo-Bosch Silvia Sposini Léa Claverie Isabel Gauthereau Stéphane Claverol Daniel Choquet Matthieu Sainlos David Perrais
author_sort	Morgane Rosendale
title	Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
title_short	Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
title_full	Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
title_fullStr	Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
title_full_unstemmed	Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
title_sort	functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ba6e9aee54e54df3b3011ac958eab9c6
work_keys_str_mv	AT morganerosendale functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT thinhungocvan functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT dolorsgrillobosch functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT silviasposini functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT leaclaverie functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT isabelgauthereau functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT stephaneclaverol functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT danielchoquet functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT matthieusainlos functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis AT davidperrais functionalrecruitmentofdynaminrequiresmultimericinteractionsforefficientendocytosis
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Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis

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