Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan

Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce mortality in patients with cancer, especially breast cancer, but their influence on second cancer risk is uncertain. This study aimed to examine whether NSAID use is associated with second cancer risk in patients with breast cancer. This populatio...

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Autores principales:	Yin-Che Lu, Pin-Tzu Chen, Mei-Chen Lin, Che-Chen Lin, Shi-Heng Wang, Yi-Jiun Pan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	NSAID breast cancer second cancer cohort study risk reduction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ba70d77f9b844b3983aa3c3cc979bfcd
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spelling	oai:doaj.org-article:ba70d77f9b844b3983aa3c3cc979bfcd2021-11-30T17:50:13ZNonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan2234-943X10.3389/fonc.2021.756143https://doaj.org/article/ba70d77f9b844b3983aa3c3cc979bfcd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.756143/fullhttps://doaj.org/toc/2234-943XNonsteroidal anti-inflammatory drugs (NSAIDs) reduce mortality in patients with cancer, especially breast cancer, but their influence on second cancer risk is uncertain. This study aimed to examine whether NSAID use is associated with second cancer risk in patients with breast cancer. This population-based propensity score-matched cohort study using Taiwan’s National Health Insurance Research Database enrolled patients with newly diagnosed breast cancer (n = 7356) with and without (n = 1839) NSAID therapy from 2000 to 2009. They were followed up until the diagnosis of second cancer, death, or end of 2011. Cox proportional hazard models were used to estimate adjusted hazard ratios (aHR). The NSAID cohort had a lower incidence rate of second cancer than the non-NSAID cohort (5.57 vs. 9.19 per 1,000 person-years), with an aHR of 0.63 (95% confidence interval (CI) 0.46–0.87). When compared with the non-NSAID cohort, the second cancer incidence was lower in patients taking non-cyclooxygenase 2 inhibitors (aHR 0.67, 95% CI 0.47–0.94) and in those receiving multiple NSAIDs during follow-up (aHR 0.55, 95% CI 0.37–0.84). A dose–response relationship existed in NSAID cumulative days. The findings demonstrate that NSAID use reduces second cancer risk in a dose-dependent manner in patients with primary breast cancer.Yin-Che LuYin-Che LuPin-Tzu ChenMei-Chen LinMei-Chen LinChe-Chen LinChe-Chen LinShi-Heng WangShi-Heng WangYi-Jiun PanFrontiers Media S.A.articleNSAIDbreast cancersecond cancercohort studyrisk reductionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NSAID breast cancer second cancer cohort study risk reduction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	NSAID breast cancer second cancer cohort study risk reduction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yin-Che Lu Yin-Che Lu Pin-Tzu Chen Mei-Chen Lin Mei-Chen Lin Che-Chen Lin Che-Chen Lin Shi-Heng Wang Shi-Heng Wang Yi-Jiun Pan Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan
description	Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce mortality in patients with cancer, especially breast cancer, but their influence on second cancer risk is uncertain. This study aimed to examine whether NSAID use is associated with second cancer risk in patients with breast cancer. This population-based propensity score-matched cohort study using Taiwan’s National Health Insurance Research Database enrolled patients with newly diagnosed breast cancer (n = 7356) with and without (n = 1839) NSAID therapy from 2000 to 2009. They were followed up until the diagnosis of second cancer, death, or end of 2011. Cox proportional hazard models were used to estimate adjusted hazard ratios (aHR). The NSAID cohort had a lower incidence rate of second cancer than the non-NSAID cohort (5.57 vs. 9.19 per 1,000 person-years), with an aHR of 0.63 (95% confidence interval (CI) 0.46–0.87). When compared with the non-NSAID cohort, the second cancer incidence was lower in patients taking non-cyclooxygenase 2 inhibitors (aHR 0.67, 95% CI 0.47–0.94) and in those receiving multiple NSAIDs during follow-up (aHR 0.55, 95% CI 0.37–0.84). A dose–response relationship existed in NSAID cumulative days. The findings demonstrate that NSAID use reduces second cancer risk in a dose-dependent manner in patients with primary breast cancer.
format	article
author	Yin-Che Lu Yin-Che Lu Pin-Tzu Chen Mei-Chen Lin Mei-Chen Lin Che-Chen Lin Che-Chen Lin Shi-Heng Wang Shi-Heng Wang Yi-Jiun Pan
author_facet	Yin-Che Lu Yin-Che Lu Pin-Tzu Chen Mei-Chen Lin Mei-Chen Lin Che-Chen Lin Che-Chen Lin Shi-Heng Wang Shi-Heng Wang Yi-Jiun Pan
author_sort	Yin-Che Lu
title	Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan
title_short	Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan
title_full	Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan
title_fullStr	Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan
title_full_unstemmed	Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan
title_sort	nonsteroidal anti-inflammatory drugs reduce second cancer risk in patients with breast cancer: a nationwide population-based propensity score-matched cohort study in taiwan
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ba70d77f9b844b3983aa3c3cc979bfcd
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Nonsteroidal Anti-Inflammatory Drugs Reduce Second Cancer Risk in Patients With Breast Cancer: A Nationwide Population-Based Propensity Score-Matched Cohort Study in Taiwan

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