Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold
Abstract The energy flow during natural photosynthesis is controlled by maintaining the spatial arrangement of pigments, employing helices as scaffolds. In this study, we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor energy transfer efficienc...
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Nature Portfolio
2017
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oai:doaj.org-article:ba717293ef804b1eb499b63cae6f7d362021-12-02T15:05:47ZPrecisely tuneable energy transfer system using peptoid helix-based molecular scaffold10.1038/s41598-017-04727-02045-2322https://doaj.org/article/ba717293ef804b1eb499b63cae6f7d362017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04727-0https://doaj.org/toc/2045-2322Abstract The energy flow during natural photosynthesis is controlled by maintaining the spatial arrangement of pigments, employing helices as scaffolds. In this study, we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor energy transfer efficiency with exceptional precision by controlling the relative distance and orientation of the two pigments. Five donor-acceptor molecular dyads were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)–Zn(i + 6)), and highly efficient energy transfer was demonstrated with estimated efficiencies ranging from 92% to 96% measured by static fluorescence emission in CH2Cl2 and from 96.3% to 97.6% using femtosecond transient absorption measurements in toluene, depending on the relative spatial arrangement of the donor-acceptor pairs. Our results suggest that the remarkable precision and tunability exhibited by nature can be achieved by mimicking the design principles of natural photosynthetic proteins.Boyeong KangWoojin YangSebok LeeSudipto MukherjeeJonathan ForstaterHanna KimByoungsook GohTae-Young KimVincent A. VoelzYoonsoo PangJiwon SeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Boyeong Kang Woojin Yang Sebok Lee Sudipto Mukherjee Jonathan Forstater Hanna Kim Byoungsook Goh Tae-Young Kim Vincent A. Voelz Yoonsoo Pang Jiwon Seo Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold |
| description |
Abstract The energy flow during natural photosynthesis is controlled by maintaining the spatial arrangement of pigments, employing helices as scaffolds. In this study, we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor energy transfer efficiency with exceptional precision by controlling the relative distance and orientation of the two pigments. Five donor-acceptor molecular dyads were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)–Zn(i + 6)), and highly efficient energy transfer was demonstrated with estimated efficiencies ranging from 92% to 96% measured by static fluorescence emission in CH2Cl2 and from 96.3% to 97.6% using femtosecond transient absorption measurements in toluene, depending on the relative spatial arrangement of the donor-acceptor pairs. Our results suggest that the remarkable precision and tunability exhibited by nature can be achieved by mimicking the design principles of natural photosynthetic proteins. |
| format |
article |
| author |
Boyeong Kang Woojin Yang Sebok Lee Sudipto Mukherjee Jonathan Forstater Hanna Kim Byoungsook Goh Tae-Young Kim Vincent A. Voelz Yoonsoo Pang Jiwon Seo |
| author_facet |
Boyeong Kang Woojin Yang Sebok Lee Sudipto Mukherjee Jonathan Forstater Hanna Kim Byoungsook Goh Tae-Young Kim Vincent A. Voelz Yoonsoo Pang Jiwon Seo |
| author_sort |
Boyeong Kang |
| title |
Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold |
| title_short |
Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold |
| title_full |
Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold |
| title_fullStr |
Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold |
| title_full_unstemmed |
Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold |
| title_sort |
precisely tuneable energy transfer system using peptoid helix-based molecular scaffold |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ba717293ef804b1eb499b63cae6f7d36 |
| work_keys_str_mv |
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1718388729012289536 |