FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis

Jeffrey Eckert,1 Brian Scott,1,2 Shelley M Lawrence,3 Michael Ihnat,4 Hala Chaaban1 1Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Department of Pediat...

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Autores principales:	Eckert J, Scott B, Lawrence SM, Ihnat M, Chaaban H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Necrotizing enterocolitis Neonatal intestinal inflammation Curcumin FLLL32 STAT3 inhibitors Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ba71a7067c5842f58252ac034fe1867c
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spelling	oai:doaj.org-article:ba71a7067c5842f58252ac034fe1867c2021-12-02T06:55:34ZFLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis1178-7031https://doaj.org/article/ba71a7067c5842f58252ac034fe1867c2017-06-01T00:00:00Zhttps://www.dovepress.com/flll32-a-curcumin-analog-ameliorates-intestinal-injury-in-necrotizing--peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Jeffrey Eckert,1 Brian Scott,1,2 Shelley M Lawrence,3 Michael Ihnat,4 Hala Chaaban1 1Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Department of Pediatrics, University of California San Diego, San Diego, CA, 4Department of Pharmaceutical Sciences, University of Oklahoma, College of Pharmacy, Oklahoma City, OK, USA Background: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premature infants. It is characterized by inflammation and leukocyte infiltration that can progress to intestinal necrosis, perforation, systemic inflammatory response, and death. In this study, we examined the effect of FLLL32, a curcumin analog, on an NEC-like neonatal intestinal injury model. Methods: NEC was induced in CD-1 mice pups using the Paneth cell ablation and Klebsiella infection model. Pups were divided into sham, NEC, and NEC + FLLL32 groups. At the end of the experiment, pups were euthanized; whole blood and small intestines were harvested. Intestinal inflammatory cytokine profile, in vivo intestinal permeability using serum fluorescein isothiocyanate-dextran, and histological injury scores were compared between the groups. Results and conclusion: FLLL32-treated pups had lower intestinal injury, improved intestinal permeability, and lower proinflammatory cytokine profiles compared to those in untreated pups with NEC. These results suggest that FLLL32 plays a protective role in NEC. Keywords: necrotizing enterocolitis, neonatal intestinal inflammation, curcumin, FLLL32, STAT3 inhibitorsEckert JScott BLawrence SMIhnat MChaaban HDove Medical PressarticleNecrotizing enterocolitisNeonatal intestinal inflammationCurcuminFLLL32STAT3 inhibitorsPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 10, Pp 75-81 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Necrotizing enterocolitis Neonatal intestinal inflammation Curcumin FLLL32 STAT3 inhibitors Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Necrotizing enterocolitis Neonatal intestinal inflammation Curcumin FLLL32 STAT3 inhibitors Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Eckert J Scott B Lawrence SM Ihnat M Chaaban H FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
description	Jeffrey Eckert,1 Brian Scott,1,2 Shelley M Lawrence,3 Michael Ihnat,4 Hala Chaaban1 1Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Department of Pediatrics, University of California San Diego, San Diego, CA, 4Department of Pharmaceutical Sciences, University of Oklahoma, College of Pharmacy, Oklahoma City, OK, USA Background: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premature infants. It is characterized by inflammation and leukocyte infiltration that can progress to intestinal necrosis, perforation, systemic inflammatory response, and death. In this study, we examined the effect of FLLL32, a curcumin analog, on an NEC-like neonatal intestinal injury model. Methods: NEC was induced in CD-1 mice pups using the Paneth cell ablation and Klebsiella infection model. Pups were divided into sham, NEC, and NEC + FLLL32 groups. At the end of the experiment, pups were euthanized; whole blood and small intestines were harvested. Intestinal inflammatory cytokine profile, in vivo intestinal permeability using serum fluorescein isothiocyanate-dextran, and histological injury scores were compared between the groups. Results and conclusion: FLLL32-treated pups had lower intestinal injury, improved intestinal permeability, and lower proinflammatory cytokine profiles compared to those in untreated pups with NEC. These results suggest that FLLL32 plays a protective role in NEC. Keywords: necrotizing enterocolitis, neonatal intestinal inflammation, curcumin, FLLL32, STAT3 inhibitors
format	article
author	Eckert J Scott B Lawrence SM Ihnat M Chaaban H
author_facet	Eckert J Scott B Lawrence SM Ihnat M Chaaban H
author_sort	Eckert J
title	FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
title_short	FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
title_full	FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
title_fullStr	FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
title_full_unstemmed	FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
title_sort	flll32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ba71a7067c5842f58252ac034fe1867c
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_version_	1718399715468378112

FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis

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