Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia

Abstract Increased levels of peripheral cytokines have been previously associated with depression in preclinical and clinical research. Although the precise nature of peripheral immune dysfunction in depression remains unclear, evidence from animal studies points towards a dysregulated response of p...

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Autores principales:	Sara Costi, Laurel S. Morris, Abigail Collins, Nicolas F. Fernandez, Manishkumar Patel, Hui Xie, Seunghee Kim-Schulze, Emily R. Stern, Katherine A. Collins, Flurin Cathomas, Michael K. Parides, Alexis E. Whitton, Diego A. Pizzagalli, Scott J. Russo, James W. Murrough
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/ba742c5afe7d476aa19d67c3d88c7bb5
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spelling	oai:doaj.org-article:ba742c5afe7d476aa19d67c3d88c7bb52021-11-07T12:17:40ZPeripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia10.1038/s41398-021-01668-12158-3188https://doaj.org/article/ba742c5afe7d476aa19d67c3d88c7bb52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01668-1https://doaj.org/toc/2158-3188Abstract Increased levels of peripheral cytokines have been previously associated with depression in preclinical and clinical research. Although the precise nature of peripheral immune dysfunction in depression remains unclear, evidence from animal studies points towards a dysregulated response of peripheral leukocytes as a risk factor for stress susceptibility. This study examined dynamic release of inflammatory blood factors from peripheral blood mononuclear cells (PBMC) in depressed patients and associations with neural and behavioral measures of reward processing. Thirty unmedicated patients meeting criteria for unipolar depressive disorder and 21 healthy control volunteers were enrolled. PBMCs were isolated from whole blood and stimulated ex vivo with lipopolysaccharide (LPS). Olink multiplex assay was used to analyze a large panel of inflammatory proteins. Participants completed functional magnetic resonance imaging with an incentive flanker task to probe neural responses to reward anticipation, as well as clinical measures of anhedonia and pleasure including the Temporal Experience of Pleasure Scale (TEPS) and the Snaith-Hamilton Pleasure Scale (SHAPS). LPS stimulation revealed larger increases in immune factors in depressed compared to healthy subjects using an aggregate immune score (t 49 = 2.83, p = 0.007). Higher peripheral immune score was associated with reduced neural responses to reward anticipation within the ventral striatum (VS) (r = −0.39, p = 0.01), and with reduced anticipation of pleasure as measured with the TEPS anticipatory sub-score (r = −0.318, p = 0.023). Our study provides new evidence suggesting that dynamic hyper-reactivity of peripheral leukocytes in depressed patients is associated with blunted activation of the brain reward system and lower subjective anticipation of pleasure.Sara CostiLaurel S. MorrisAbigail CollinsNicolas F. FernandezManishkumar PatelHui XieSeunghee Kim-SchulzeEmily R. SternKatherine A. CollinsFlurin CathomasMichael K. ParidesAlexis E. WhittonDiego A. PizzagalliScott J. RussoJames W. MurroughNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Sara Costi Laurel S. Morris Abigail Collins Nicolas F. Fernandez Manishkumar Patel Hui Xie Seunghee Kim-Schulze Emily R. Stern Katherine A. Collins Flurin Cathomas Michael K. Parides Alexis E. Whitton Diego A. Pizzagalli Scott J. Russo James W. Murrough Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
description	Abstract Increased levels of peripheral cytokines have been previously associated with depression in preclinical and clinical research. Although the precise nature of peripheral immune dysfunction in depression remains unclear, evidence from animal studies points towards a dysregulated response of peripheral leukocytes as a risk factor for stress susceptibility. This study examined dynamic release of inflammatory blood factors from peripheral blood mononuclear cells (PBMC) in depressed patients and associations with neural and behavioral measures of reward processing. Thirty unmedicated patients meeting criteria for unipolar depressive disorder and 21 healthy control volunteers were enrolled. PBMCs were isolated from whole blood and stimulated ex vivo with lipopolysaccharide (LPS). Olink multiplex assay was used to analyze a large panel of inflammatory proteins. Participants completed functional magnetic resonance imaging with an incentive flanker task to probe neural responses to reward anticipation, as well as clinical measures of anhedonia and pleasure including the Temporal Experience of Pleasure Scale (TEPS) and the Snaith-Hamilton Pleasure Scale (SHAPS). LPS stimulation revealed larger increases in immune factors in depressed compared to healthy subjects using an aggregate immune score (t 49 = 2.83, p = 0.007). Higher peripheral immune score was associated with reduced neural responses to reward anticipation within the ventral striatum (VS) (r = −0.39, p = 0.01), and with reduced anticipation of pleasure as measured with the TEPS anticipatory sub-score (r = −0.318, p = 0.023). Our study provides new evidence suggesting that dynamic hyper-reactivity of peripheral leukocytes in depressed patients is associated with blunted activation of the brain reward system and lower subjective anticipation of pleasure.
format	article
author	Sara Costi Laurel S. Morris Abigail Collins Nicolas F. Fernandez Manishkumar Patel Hui Xie Seunghee Kim-Schulze Emily R. Stern Katherine A. Collins Flurin Cathomas Michael K. Parides Alexis E. Whitton Diego A. Pizzagalli Scott J. Russo James W. Murrough
author_facet	Sara Costi Laurel S. Morris Abigail Collins Nicolas F. Fernandez Manishkumar Patel Hui Xie Seunghee Kim-Schulze Emily R. Stern Katherine A. Collins Flurin Cathomas Michael K. Parides Alexis E. Whitton Diego A. Pizzagalli Scott J. Russo James W. Murrough
author_sort	Sara Costi
title	Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
title_short	Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
title_full	Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
title_fullStr	Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
title_full_unstemmed	Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
title_sort	peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/ba742c5afe7d476aa19d67c3d88c7bb5
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Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia

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