Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits
Baodong Zhao,1,2 Xin Li,1,2 Hao Xu,1,2 Yaping Jiang,1,2 Dashan Wang,1,2 Ran Liu1,2 1Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People’s Republic of China; 2School of Stomatology, Qingdao University, Qingdao, Shandong 266001, Pe...
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Dove Medical Press
2020
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oai:doaj.org-article:ba744e3f218b493d987789053f279e922021-12-02T08:05:32ZInfluence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits1178-2013https://doaj.org/article/ba744e3f218b493d987789053f279e922020-03-01T00:00:00Zhttps://www.dovepress.com/influence-of-simvastatin-strontium-hydroxyapatite-coated-implant-forme-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Baodong Zhao,1,2 Xin Li,1,2 Hao Xu,1,2 Yaping Jiang,1,2 Dashan Wang,1,2 Ran Liu1,2 1Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People’s Republic of China; 2School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People’s Republic of ChinaCorrespondence: Xin LiThe Affiliated Hospital of Qingdao University No. 59 Haier Road, Laoshan District, Qingdao, Shandong 266001, People’s Republic of ChinaTel +86532-82913583Email lixindentist@126.comPurpose: Enhancing osteointegration of implants in osteoporosis patients is a necessity since implantations frequently fail in these patients. The aim of this work is to study how simvastatin-strontium-hydroxyapatite coated implants perform in rabbits with osteoporosis.Materials and Methods: Crystalline HA and Sr-HA oxide film were prepared through micro-arc oxidation. Surface characterization including morphology, roughness, element composition, phase composition, hydrophilicity were then evaluated. Simvastatin loaded on porous films through immersion, and the effects of coatings on osteointegration in osteoporotic rabbits were investigated. All samples were obtained after 4, 8 and 12 weeks of healing. Some of them were subjected to biomechanical tests and others were subjected to histological and histomorphometric analysis.Results: Coatings exhibited a microporous network structure with appropriate roughness and high hydrophilicity. Compared to control HA and machined surface implants, simvastatin-Sr-HA coated implants exhibited marked improvements in osteointegration, which is characterized by a quicker mineralization deposition rate, good bone formation mode (large amount of contact osteogenesis and a small amount of distance osteogenesis) and increased bone-to-implant contact and pull-out strength.Conclusion: These biological parameters demonstrate the excellent osteoconductivity of simvastatin-Sr-HA coatings in the osteoporotic state. Overall, this suggests that simvastatin-Sr-HA coatings would be applicable in poor-quality bones of patients experiencing osteoporosis.Keywords: osteoporosis, micro-arc oxidation, strontium, simvastatin, osteointegration, dental implantsZhao BLi XXu HJiang YWang DLiu RDove Medical Pressarticleosteoporosismicro-arc oxidationstrontiumsimvastatinosteointegrationdental implantsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 1797-1807 (2020) |
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osteoporosis micro-arc oxidation strontium simvastatin osteointegration dental implants Medicine (General) R5-920 |
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osteoporosis micro-arc oxidation strontium simvastatin osteointegration dental implants Medicine (General) R5-920 Zhao B Li X Xu H Jiang Y Wang D Liu R Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits |
| description |
Baodong Zhao,1,2 Xin Li,1,2 Hao Xu,1,2 Yaping Jiang,1,2 Dashan Wang,1,2 Ran Liu1,2 1Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People’s Republic of China; 2School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People’s Republic of ChinaCorrespondence: Xin LiThe Affiliated Hospital of Qingdao University No. 59 Haier Road, Laoshan District, Qingdao, Shandong 266001, People’s Republic of ChinaTel +86532-82913583Email lixindentist@126.comPurpose: Enhancing osteointegration of implants in osteoporosis patients is a necessity since implantations frequently fail in these patients. The aim of this work is to study how simvastatin-strontium-hydroxyapatite coated implants perform in rabbits with osteoporosis.Materials and Methods: Crystalline HA and Sr-HA oxide film were prepared through micro-arc oxidation. Surface characterization including morphology, roughness, element composition, phase composition, hydrophilicity were then evaluated. Simvastatin loaded on porous films through immersion, and the effects of coatings on osteointegration in osteoporotic rabbits were investigated. All samples were obtained after 4, 8 and 12 weeks of healing. Some of them were subjected to biomechanical tests and others were subjected to histological and histomorphometric analysis.Results: Coatings exhibited a microporous network structure with appropriate roughness and high hydrophilicity. Compared to control HA and machined surface implants, simvastatin-Sr-HA coated implants exhibited marked improvements in osteointegration, which is characterized by a quicker mineralization deposition rate, good bone formation mode (large amount of contact osteogenesis and a small amount of distance osteogenesis) and increased bone-to-implant contact and pull-out strength.Conclusion: These biological parameters demonstrate the excellent osteoconductivity of simvastatin-Sr-HA coatings in the osteoporotic state. Overall, this suggests that simvastatin-Sr-HA coatings would be applicable in poor-quality bones of patients experiencing osteoporosis.Keywords: osteoporosis, micro-arc oxidation, strontium, simvastatin, osteointegration, dental implants |
| format |
article |
| author |
Zhao B Li X Xu H Jiang Y Wang D Liu R |
| author_facet |
Zhao B Li X Xu H Jiang Y Wang D Liu R |
| author_sort |
Zhao B |
| title |
Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits |
| title_short |
Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits |
| title_full |
Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits |
| title_fullStr |
Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits |
| title_full_unstemmed |
Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits |
| title_sort |
influence of simvastatin-strontium-hydroxyapatite coated implant formed by micro-arc oxidation and immersion method on osteointegration in osteoporotic rabbits |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/ba744e3f218b493d987789053f279e92 |
| work_keys_str_mv |
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