Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey

Abstract New Jersey was an early epicenter for the COVID-19 pandemic in the United States, yet information on hospitalized COVID-19 patients from this area is scarce. This study aimed to provide data on demographics and clinical features of a hospitalized patient population who were confirmed with i...

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Autores principales:	Yanan Zhao, Marcus H. Cunningham, Jose R. Mediavilla, Steven Park, Sean Fitzgerald, Hee Sang Ahn, Xiangyang Li, Caixin Zhan, Tao Hong, Gary Munk, Kar Fai Chow, David S. Perlin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba78d709e9fa4211a6e3fd27edbe9586
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spelling	oai:doaj.org-article:ba78d709e9fa4211a6e3fd27edbe95862021-12-02T11:02:18ZDiagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey10.1038/s41598-021-83959-72045-2322https://doaj.org/article/ba78d709e9fa4211a6e3fd27edbe95862021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83959-7https://doaj.org/toc/2045-2322Abstract New Jersey was an early epicenter for the COVID-19 pandemic in the United States, yet information on hospitalized COVID-19 patients from this area is scarce. This study aimed to provide data on demographics and clinical features of a hospitalized patient population who were confirmed with infection by our in-house (CDI) real-time reverse-transcription polymerase chain reaction (RT-PCR) test. We included consecutive patients who were admitted to Hackensack Meridian Health system hospitals with laboratory-confirmed diagnoses of COVID-19 at Hackensack University Medical Center by the CDI virus test between March 12, 2020, and April 8, 2020. Clinical data and viral testing results were collected and analyzed for characteristics associated with outcomes, as well as the correlation with viral load. A total of 722 patients were included in the study, with a median age of 63 (interquartile range (IQR), 51–75) and 272 (37.7%) females. Mortality of this case series was 25.8%, with a statistically significant linear increase observed from age 40 to ≥ 80 by 10-year intervals. Viral load, as indicated by the cycle of threshold (Ct) values from the RT-PCR test, was significantly higher in the oldest patient group (≥ 80), and inversely correlated with survival. This is the first report to describe the clinical characteristics and outcomes in a large hospitalized COVID-19 patient series from New Jersey. Findings from this study are valuable to the ongoing response of both nationwide healthcare networks and the medical research community.Yanan ZhaoMarcus H. CunninghamJose R. MediavillaSteven ParkSean FitzgeraldHee Sang AhnXiangyang LiCaixin ZhanTao HongGary MunkKar Fai ChowDavid S. PerlinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanan Zhao Marcus H. Cunningham Jose R. Mediavilla Steven Park Sean Fitzgerald Hee Sang Ahn Xiangyang Li Caixin Zhan Tao Hong Gary Munk Kar Fai Chow David S. Perlin Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
description	Abstract New Jersey was an early epicenter for the COVID-19 pandemic in the United States, yet information on hospitalized COVID-19 patients from this area is scarce. This study aimed to provide data on demographics and clinical features of a hospitalized patient population who were confirmed with infection by our in-house (CDI) real-time reverse-transcription polymerase chain reaction (RT-PCR) test. We included consecutive patients who were admitted to Hackensack Meridian Health system hospitals with laboratory-confirmed diagnoses of COVID-19 at Hackensack University Medical Center by the CDI virus test between March 12, 2020, and April 8, 2020. Clinical data and viral testing results were collected and analyzed for characteristics associated with outcomes, as well as the correlation with viral load. A total of 722 patients were included in the study, with a median age of 63 (interquartile range (IQR), 51–75) and 272 (37.7%) females. Mortality of this case series was 25.8%, with a statistically significant linear increase observed from age 40 to ≥ 80 by 10-year intervals. Viral load, as indicated by the cycle of threshold (Ct) values from the RT-PCR test, was significantly higher in the oldest patient group (≥ 80), and inversely correlated with survival. This is the first report to describe the clinical characteristics and outcomes in a large hospitalized COVID-19 patient series from New Jersey. Findings from this study are valuable to the ongoing response of both nationwide healthcare networks and the medical research community.
format	article
author	Yanan Zhao Marcus H. Cunningham Jose R. Mediavilla Steven Park Sean Fitzgerald Hee Sang Ahn Xiangyang Li Caixin Zhan Tao Hong Gary Munk Kar Fai Chow David S. Perlin
author_facet	Yanan Zhao Marcus H. Cunningham Jose R. Mediavilla Steven Park Sean Fitzgerald Hee Sang Ahn Xiangyang Li Caixin Zhan Tao Hong Gary Munk Kar Fai Chow David S. Perlin
author_sort	Yanan Zhao
title	Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
title_short	Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
title_full	Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
title_fullStr	Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
title_full_unstemmed	Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
title_sort	diagnosis, clinical characteristics, and outcomes of covid-19 patients from a large healthcare system in northern new jersey
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba78d709e9fa4211a6e3fd27edbe9586
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Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey

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