Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease
Accumulating evidence suggests that disruption of autophagy is associated with neurodegeneration. Here the authors show that Plekhg5 acts as a GEF for Rab26, a small GTPase that promotes the autophagy of synaptic vesicles in neurons; mice lacking Plekgh5 develop late-onset motoneuron degeneration.
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Nature Portfolio
2017
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oai:doaj.org-article:ba7baaeefffb431d9f931d09c46a1a222021-12-02T14:40:46ZPlekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease10.1038/s41467-017-00689-z2041-1723https://doaj.org/article/ba7baaeefffb431d9f931d09c46a1a222017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00689-zhttps://doaj.org/toc/2041-1723Accumulating evidence suggests that disruption of autophagy is associated with neurodegeneration. Here the authors show that Plekhg5 acts as a GEF for Rab26, a small GTPase that promotes the autophagy of synaptic vesicles in neurons; mice lacking Plekgh5 develop late-onset motoneuron degeneration.Patrick LüningschrörBeyenech BinottiBenjamin DombertPeter HeimannAngel Perez-LaraCarsten SlottaNadine Thau-HabermannCora R. von CollenbergFranziska KarlMarkus DammeArie HorowitzIsabelle MaystadtAnnette FüchtbauerErnst-Martin FüchtbauerSibylle JablonkaRobert BlumNurcan ÜçeylerSusanne PetriBarbara KaltschmidtReinhard JahnChristian KaltschmidtMichael SendtnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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DOAJ |
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| topic |
Science Q |
| spellingShingle |
Science Q Patrick Lüningschrör Beyenech Binotti Benjamin Dombert Peter Heimann Angel Perez-Lara Carsten Slotta Nadine Thau-Habermann Cora R. von Collenberg Franziska Karl Markus Damme Arie Horowitz Isabelle Maystadt Annette Füchtbauer Ernst-Martin Füchtbauer Sibylle Jablonka Robert Blum Nurcan Üçeyler Susanne Petri Barbara Kaltschmidt Reinhard Jahn Christian Kaltschmidt Michael Sendtner Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease |
| description |
Accumulating evidence suggests that disruption of autophagy is associated with neurodegeneration. Here the authors show that Plekhg5 acts as a GEF for Rab26, a small GTPase that promotes the autophagy of synaptic vesicles in neurons; mice lacking Plekgh5 develop late-onset motoneuron degeneration. |
| format |
article |
| author |
Patrick Lüningschrör Beyenech Binotti Benjamin Dombert Peter Heimann Angel Perez-Lara Carsten Slotta Nadine Thau-Habermann Cora R. von Collenberg Franziska Karl Markus Damme Arie Horowitz Isabelle Maystadt Annette Füchtbauer Ernst-Martin Füchtbauer Sibylle Jablonka Robert Blum Nurcan Üçeyler Susanne Petri Barbara Kaltschmidt Reinhard Jahn Christian Kaltschmidt Michael Sendtner |
| author_facet |
Patrick Lüningschrör Beyenech Binotti Benjamin Dombert Peter Heimann Angel Perez-Lara Carsten Slotta Nadine Thau-Habermann Cora R. von Collenberg Franziska Karl Markus Damme Arie Horowitz Isabelle Maystadt Annette Füchtbauer Ernst-Martin Füchtbauer Sibylle Jablonka Robert Blum Nurcan Üçeyler Susanne Petri Barbara Kaltschmidt Reinhard Jahn Christian Kaltschmidt Michael Sendtner |
| author_sort |
Patrick Lüningschrör |
| title |
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease |
| title_short |
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease |
| title_full |
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease |
| title_fullStr |
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease |
| title_full_unstemmed |
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease |
| title_sort |
plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ba7baaeefffb431d9f931d09c46a1a22 |
| work_keys_str_mv |
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