Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH

Chakraborty et al. show that phagocyte NADPH oxidase (NOX2) collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins. Salmonella responds by shifting redox balance from respiration to glycolysis and fermentation, thereby facilitating folding of...

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Autores principales: Sangeeta Chakraborty, Lin Liu, Liam Fitzsimmons, Steffen Porwollik, Ju-Sim Kim, Prerak Desai, Michael McClelland, Andres Vazquez-Torres
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ba7d19a901384298983d522cad6c87de
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Sumario:Chakraborty et al. show that phagocyte NADPH oxidase (NOX2) collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins. Salmonella responds by shifting redox balance from respiration to glycolysis and fermentation, thereby facilitating folding of periplasmic functions.