Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH

Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH

Chakraborty et al. show that phagocyte NADPH oxidase (NOX2) collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins. Salmonella responds by shifting redox balance from respiration to glycolysis and fermentation, thereby facilitating folding of...

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Autores principales: Sangeeta Chakraborty, Lin Liu, Liam Fitzsimmons, Steffen Porwollik, Ju-Sim Kim, Prerak Desai, Michael McClelland, Andres Vazquez-Torres
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ba7d19a901384298983d522cad6c87de
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spelling oai:doaj.org-article:ba7d19a901384298983d522cad6c87de2021-12-02T16:49:45ZGlycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH10.1038/s41467-020-15604-22041-1723https://doaj.org/article/ba7d19a901384298983d522cad6c87de2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15604-2https://doaj.org/toc/2041-1723Chakraborty et al. show that phagocyte NADPH oxidase (NOX2) collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins. Salmonella responds by shifting redox balance from respiration to glycolysis and fermentation, thereby facilitating folding of periplasmic functions.Sangeeta ChakrabortyLin LiuLiam FitzsimmonsSteffen PorwollikJu-Sim KimPrerak DesaiMichael McClellandAndres Vazquez-TorresNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sangeeta Chakraborty
Lin Liu
Liam Fitzsimmons
Steffen Porwollik
Ju-Sim Kim
Prerak Desai
Michael McClelland
Andres Vazquez-Torres
Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH
description Chakraborty et al. show that phagocyte NADPH oxidase (NOX2) collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins. Salmonella responds by shifting redox balance from respiration to glycolysis and fermentation, thereby facilitating folding of periplasmic functions.
format article
author Sangeeta Chakraborty
Lin Liu
Liam Fitzsimmons
Steffen Porwollik
Ju-Sim Kim
Prerak Desai
Michael McClelland
Andres Vazquez-Torres
author_facet Sangeeta Chakraborty
Lin Liu
Liam Fitzsimmons
Steffen Porwollik
Ju-Sim Kim
Prerak Desai
Michael McClelland
Andres Vazquez-Torres
author_sort Sangeeta Chakraborty
title Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH
title_short Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH
title_full Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH
title_fullStr Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH
title_full_unstemmed Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH
title_sort glycolytic reprograming in salmonella counters nox2-mediated dissipation of δph
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ba7d19a901384298983d522cad6c87de
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AT liamfitzsimmons glycolyticreprograminginsalmonellacountersnox2mediateddissipationofdph
AT steffenporwollik glycolyticreprograminginsalmonellacountersnox2mediateddissipationofdph
AT jusimkim glycolyticreprograminginsalmonellacountersnox2mediateddissipationofdph
AT prerakdesai glycolyticreprograminginsalmonellacountersnox2mediateddissipationofdph
AT michaelmcclelland glycolyticreprograminginsalmonellacountersnox2mediateddissipationofdph
AT andresvazqueztorres glycolyticreprograminginsalmonellacountersnox2mediateddissipationofdph
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