Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

Elder et al. investigated the de novo proteome in isolated hippocampal slices of young APP/PS1 Alzheimer’s model mice and revealed that large-scale changes in protein synthesis precede symptom onset. These results suggest that broad dysregulation of protein synthesis could contribute toward cellular...

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Autores principales:	Megan K. Elder, Hediye Erdjument-Bromage, Mauricio M. Oliveira, Maggie Mamcarz, Thomas A. Neubert, Eric Klann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ba83267e1a204a7482de629bf9b21435
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spelling	oai:doaj.org-article:ba83267e1a204a7482de629bf9b214352021-12-02T18:18:31ZAge-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model10.1038/s42003-021-02324-62399-3642https://doaj.org/article/ba83267e1a204a7482de629bf9b214352021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02324-6https://doaj.org/toc/2399-3642Elder et al. investigated the de novo proteome in isolated hippocampal slices of young APP/PS1 Alzheimer’s model mice and revealed that large-scale changes in protein synthesis precede symptom onset. These results suggest that broad dysregulation of protein synthesis could contribute toward cellular dysfunction in Alzheimer’s disease.Megan K. ElderHediye Erdjument-BromageMauricio M. OliveiraMaggie MamcarzThomas A. NeubertEric KlannNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Megan K. Elder Hediye Erdjument-Bromage Mauricio M. Oliveira Maggie Mamcarz Thomas A. Neubert Eric Klann Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model
description	Elder et al. investigated the de novo proteome in isolated hippocampal slices of young APP/PS1 Alzheimer’s model mice and revealed that large-scale changes in protein synthesis precede symptom onset. These results suggest that broad dysregulation of protein synthesis could contribute toward cellular dysfunction in Alzheimer’s disease.
format	article
author	Megan K. Elder Hediye Erdjument-Bromage Mauricio M. Oliveira Maggie Mamcarz Thomas A. Neubert Eric Klann
author_facet	Megan K. Elder Hediye Erdjument-Bromage Mauricio M. Oliveira Maggie Mamcarz Thomas A. Neubert Eric Klann
author_sort	Megan K. Elder
title	Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model
title_short	Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model
title_full	Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model
title_fullStr	Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model
title_full_unstemmed	Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model
title_sort	age-dependent shift in the de novo proteome accompanies pathogenesis in an alzheimer’s disease mouse model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba83267e1a204a7482de629bf9b21435
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Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

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