Impact of carbon monoxide poisoning on the risk of breast cancer

Abstract Carbon monoxide (CO) is a toxic gas and an endogenous signaling molecule. Some studies involving cell lines have revealed the potential antibreast cancer effects of CO. Data on such effects in humans, however, are limited. Thus, we conducted a study on patients with CO poisoning (COP) to ev...

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Autores principales:	Chien-Cheng Huang, Chung-Han Ho, Yi-Chen Chen, Chien-Chin Hsu, Hung-Jung Lin, Yu-Feng Tian, Jhi-Joung Wang, How-Ran Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba83cadb28be44b886d6110c02f7a379
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spelling	oai:doaj.org-article:ba83cadb28be44b886d6110c02f7a3792021-12-02T15:10:06ZImpact of carbon monoxide poisoning on the risk of breast cancer10.1038/s41598-020-77371-w2045-2322https://doaj.org/article/ba83cadb28be44b886d6110c02f7a3792020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77371-whttps://doaj.org/toc/2045-2322Abstract Carbon monoxide (CO) is a toxic gas and an endogenous signaling molecule. Some studies involving cell lines have revealed the potential antibreast cancer effects of CO. Data on such effects in humans, however, are limited. Thus, we conducted a study on patients with CO poisoning (COP) to evaluate the effects of CO on the risk of breast cancer. We identified female patients who were diagnosed with COP over the period of 2002 and 2009 from the Nationwide Poisoning Database of Taiwan. For comparison, we selected females without COP from the National Health Insurance Research Database. Participants in the COP and comparison cohorts were matched on the index year, age, monthly income, and geographic region of residence at a 1:6 ratio. We followed up the two cohorts until the end of 2014 and compared their risks of developing breast cancer. We included 7053 participants with COP and 42,318 participants without COP. Participants with COP were at a lower risk of developing breast cancer than those without COP (0.7% vs. 1.0%, p < 0.001). Cox proportional hazard regression analyses revealed that COP was associated with a hazard ratio of 0.67 (95% confidence interval [95% CI] 0.50–0.90) for breast cancer after we adjusted for age, monthly income, geographic region, and comorbidities of hypertension, diabetes, and hyperlipidemia. Our result provides evidence for the potential protective effects of CO against breast cancer in humans. Further studies that directly evaluate the potential effects are warranted.Chien-Cheng HuangChung-Han HoYi-Chen ChenChien-Chin HsuHung-Jung LinYu-Feng TianJhi-Joung WangHow-Ran GuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chien-Cheng Huang Chung-Han Ho Yi-Chen Chen Chien-Chin Hsu Hung-Jung Lin Yu-Feng Tian Jhi-Joung Wang How-Ran Guo Impact of carbon monoxide poisoning on the risk of breast cancer
description	Abstract Carbon monoxide (CO) is a toxic gas and an endogenous signaling molecule. Some studies involving cell lines have revealed the potential antibreast cancer effects of CO. Data on such effects in humans, however, are limited. Thus, we conducted a study on patients with CO poisoning (COP) to evaluate the effects of CO on the risk of breast cancer. We identified female patients who were diagnosed with COP over the period of 2002 and 2009 from the Nationwide Poisoning Database of Taiwan. For comparison, we selected females without COP from the National Health Insurance Research Database. Participants in the COP and comparison cohorts were matched on the index year, age, monthly income, and geographic region of residence at a 1:6 ratio. We followed up the two cohorts until the end of 2014 and compared their risks of developing breast cancer. We included 7053 participants with COP and 42,318 participants without COP. Participants with COP were at a lower risk of developing breast cancer than those without COP (0.7% vs. 1.0%, p < 0.001). Cox proportional hazard regression analyses revealed that COP was associated with a hazard ratio of 0.67 (95% confidence interval [95% CI] 0.50–0.90) for breast cancer after we adjusted for age, monthly income, geographic region, and comorbidities of hypertension, diabetes, and hyperlipidemia. Our result provides evidence for the potential protective effects of CO against breast cancer in humans. Further studies that directly evaluate the potential effects are warranted.
format	article
author	Chien-Cheng Huang Chung-Han Ho Yi-Chen Chen Chien-Chin Hsu Hung-Jung Lin Yu-Feng Tian Jhi-Joung Wang How-Ran Guo
author_facet	Chien-Cheng Huang Chung-Han Ho Yi-Chen Chen Chien-Chin Hsu Hung-Jung Lin Yu-Feng Tian Jhi-Joung Wang How-Ran Guo
author_sort	Chien-Cheng Huang
title	Impact of carbon monoxide poisoning on the risk of breast cancer
title_short	Impact of carbon monoxide poisoning on the risk of breast cancer
title_full	Impact of carbon monoxide poisoning on the risk of breast cancer
title_fullStr	Impact of carbon monoxide poisoning on the risk of breast cancer
title_full_unstemmed	Impact of carbon monoxide poisoning on the risk of breast cancer
title_sort	impact of carbon monoxide poisoning on the risk of breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ba83cadb28be44b886d6110c02f7a379
work_keys_str_mv	AT chienchenghuang impactofcarbonmonoxidepoisoningontheriskofbreastcancer AT chunghanho impactofcarbonmonoxidepoisoningontheriskofbreastcancer AT yichenchen impactofcarbonmonoxidepoisoningontheriskofbreastcancer AT chienchinhsu impactofcarbonmonoxidepoisoningontheriskofbreastcancer AT hungjunglin impactofcarbonmonoxidepoisoningontheriskofbreastcancer AT yufengtian impactofcarbonmonoxidepoisoningontheriskofbreastcancer AT jhijoungwang impactofcarbonmonoxidepoisoningontheriskofbreastcancer AT howranguo impactofcarbonmonoxidepoisoningontheriskofbreastcancer
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Impact of carbon monoxide poisoning on the risk of breast cancer

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