Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells

Abstract Placental dysfunction is related to the pathogenesis of preeclampsia and fetal growth restriction, but there is no effective treatment for it. Recently, various functional three-dimensional organs have been generated from human induced-pluripotent cells (iPSCs), and the transplantation of t...

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Autores principales:	Mai Sato, Asako Inohaya, Eriko Yasuda, Haruta Mogami, Yoshitsugu Chigusa, Kaoru Kawasaki, Yosuke Kawamura, Yusuke Ueda, Hiroshi Takai, Masaki Mandai, Eiji Kondoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba8c6dea8150421bb252c564d16f6054
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spelling	oai:doaj.org-article:ba8c6dea8150421bb252c564d16f60542021-12-02T16:14:47ZThree-dimensional human placenta-like bud synthesized from induced pluripotent stem cells10.1038/s41598-021-93766-92045-2322https://doaj.org/article/ba8c6dea8150421bb252c564d16f60542021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93766-9https://doaj.org/toc/2045-2322Abstract Placental dysfunction is related to the pathogenesis of preeclampsia and fetal growth restriction, but there is no effective treatment for it. Recently, various functional three-dimensional organs have been generated from human induced-pluripotent cells (iPSCs), and the transplantation of these iPSCs-derived organs has alleviated liver failure or diabetes mellitus in mouse models. Here we successfully generated a three-dimensional placental organ bud from human iPSCs. The iPSCs differentiated into various lineages of trophoblasts such as cytotrophoblast-like, syncytiotrophoblast-like, and extravillous trophoblast-like cells, forming organized layers in the bud. Placental buds were transplanted to the murine uterus, where 22% of the buds were successfully engrafted. These iPSC-derived placental organ buds could serve as a new model for the study of placental function and pathology.Mai SatoAsako InohayaEriko YasudaHaruta MogamiYoshitsugu ChigusaKaoru KawasakiYosuke KawamuraYusuke UedaHiroshi TakaiMasaki MandaiEiji KondohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mai Sato Asako Inohaya Eriko Yasuda Haruta Mogami Yoshitsugu Chigusa Kaoru Kawasaki Yosuke Kawamura Yusuke Ueda Hiroshi Takai Masaki Mandai Eiji Kondoh Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
description	Abstract Placental dysfunction is related to the pathogenesis of preeclampsia and fetal growth restriction, but there is no effective treatment for it. Recently, various functional three-dimensional organs have been generated from human induced-pluripotent cells (iPSCs), and the transplantation of these iPSCs-derived organs has alleviated liver failure or diabetes mellitus in mouse models. Here we successfully generated a three-dimensional placental organ bud from human iPSCs. The iPSCs differentiated into various lineages of trophoblasts such as cytotrophoblast-like, syncytiotrophoblast-like, and extravillous trophoblast-like cells, forming organized layers in the bud. Placental buds were transplanted to the murine uterus, where 22% of the buds were successfully engrafted. These iPSC-derived placental organ buds could serve as a new model for the study of placental function and pathology.
format	article
author	Mai Sato Asako Inohaya Eriko Yasuda Haruta Mogami Yoshitsugu Chigusa Kaoru Kawasaki Yosuke Kawamura Yusuke Ueda Hiroshi Takai Masaki Mandai Eiji Kondoh
author_facet	Mai Sato Asako Inohaya Eriko Yasuda Haruta Mogami Yoshitsugu Chigusa Kaoru Kawasaki Yosuke Kawamura Yusuke Ueda Hiroshi Takai Masaki Mandai Eiji Kondoh
author_sort	Mai Sato
title	Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
title_short	Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
title_full	Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
title_fullStr	Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
title_full_unstemmed	Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
title_sort	three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba8c6dea8150421bb252c564d16f6054
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_version_	1718384315194146816

Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells

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