Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender

ABSTRACT Transmission of antibiotic resistance genes may be mediated by a variety of molecular mechanisms, from mobility of small genetic elements to clonal spread. Since 1997, the carbapenem-hydrolyzing enzyme Klebsiella pneumoniae carbapenemase (KPC) has spread in the United States and across the...

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Autores principales:	Amos Adler, Yehuda Carmeli
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2011
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ba8fe0b9c731464cbff215613a22f4bd
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spelling	oai:doaj.org-article:ba8fe0b9c731464cbff215613a22f4bd2021-11-15T15:38:49ZDissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender10.1128/mBio.00280-112150-7511https://doaj.org/article/ba8fe0b9c731464cbff215613a22f4bd2011-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00280-11https://doaj.org/toc/2150-7511ABSTRACT Transmission of antibiotic resistance genes may be mediated by a variety of molecular mechanisms, from mobility of small genetic elements to clonal spread. Since 1997, the carbapenem-hydrolyzing enzyme Klebsiella pneumoniae carbapenemase (KPC) has spread in the United States and across the world, mainly via a single K. pneumoniae clone, sequence type 258. By tracking the trail of dissemination of the blaKPC gene inside their institution, Mathers et al. (mBio 2:e00204–11, 2011) have shown evidence of the ability of this gene to spread by several modes, including plasmid transfer and clonal spread. The ever-evolving modes of transmission of resistance genes challenge our ability to detect, track, and eventually control the spread of what has become a major threat to hospitalized patients worldwide.Amos AdlerYehuda CarmeliAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 2, Iss 6 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Amos Adler Yehuda Carmeli Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender
description	ABSTRACT Transmission of antibiotic resistance genes may be mediated by a variety of molecular mechanisms, from mobility of small genetic elements to clonal spread. Since 1997, the carbapenem-hydrolyzing enzyme Klebsiella pneumoniae carbapenemase (KPC) has spread in the United States and across the world, mainly via a single K. pneumoniae clone, sequence type 258. By tracking the trail of dissemination of the blaKPC gene inside their institution, Mathers et al. (mBio 2:e00204–11, 2011) have shown evidence of the ability of this gene to spread by several modes, including plasmid transfer and clonal spread. The ever-evolving modes of transmission of resistance genes challenge our ability to detect, track, and eventually control the spread of what has become a major threat to hospitalized patients worldwide.
format	article
author	Amos Adler Yehuda Carmeli
author_facet	Amos Adler Yehuda Carmeli
author_sort	Amos Adler
title	Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender
title_short	Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender
title_full	Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender
title_fullStr	Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender
title_full_unstemmed	Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender
title_sort	dissemination of the <named-content content-type="genus-species">klebsiella pneumoniae</named-content> carbapenemase in the health care settings: tracking the trails of an elusive offender
publisher	American Society for Microbiology
publishDate	2011
url	https://doaj.org/article/ba8fe0b9c731464cbff215613a22f4bd
work_keys_str_mv	AT amosadler disseminationofthenamedcontentcontenttypegenusspeciesklebsiellapneumoniaenamedcontentcarbapenemaseinthehealthcaresettingstrackingthetrailsofanelusiveoffender AT yehudacarmeli disseminationofthenamedcontentcontenttypegenusspeciesklebsiellapneumoniaenamedcontentcarbapenemaseinthehealthcaresettingstrackingthetrailsofanelusiveoffender
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Dissemination of the <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender

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