Objective acoustic quantification of phonatory dysfunction in Huntington's disease.

<h4>Purpose</h4>Although speech motor changes are reported as a common sign of Huntington's disease (HD), the most prominent signs of voice dysfunction remain unknown. The aim of the current study was to explore specific changes in phonatory function in subjects with HD.<h4>Me...

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Autores principales:	Jan Rusz, Jiří Klempíř, Eva Baborová, Tereza Tykalová, Veronika Majerová, Roman Cmejla, Evžen Růžička, Jan Roth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba920f4a00c647ceb46824f577b32936
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spelling	oai:doaj.org-article:ba920f4a00c647ceb46824f577b329362021-11-18T07:42:27ZObjective acoustic quantification of phonatory dysfunction in Huntington's disease.1932-620310.1371/journal.pone.0065881https://doaj.org/article/ba920f4a00c647ceb46824f577b329362013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762447/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>Although speech motor changes are reported as a common sign of Huntington's disease (HD), the most prominent signs of voice dysfunction remain unknown. The aim of the current study was to explore specific changes in phonatory function in subjects with HD.<h4>Method</h4>34 subjects with HD and 34 age- and sex-matched healthy controls were examined. Participants performed sustained vowel phonation for subsequent analyses of airflow insufficiency, aperiodicity, irregular vibrations of vocal folds, signal perturbations, increased noise, and articulation deficiency. In total, 272 phonations were collected and 12 voice parameters were extracted. Subsequently, a predictive model was built to find the most salient patterns of voice disorders in HD. The results were also correlated with disease severity according to the Unified HD Rating Scale (UHDRS) motor score.<h4>Results</h4>Subjects with HD showed deterioration in all investigated phonatory functions. Irregular pitch fluctuations, sudden phonation interruption, increased noise, and misplacement of articulators were found to be most significant patterns of phonatory dysfunction in HD (p<0.001). The combination of these four dysphonia aspects contributed to the best classification performance of 94.1% (sensitivity: 95.1%; specificity: 93.2%) in the separation of HD patients from healthy participants. Our results further indicated stronger associations between sudden phonation interruption and voluntary components of the UHDRS (r = -0.48, p<0.01) and between misplacement of articulators and involuntary components of the UHDRS (r = 0.52, p<0.01).<h4>Conclusions</h4>Our configuration of phonatory features can detect subtle voice abnormalities in subjects with HD. As impairment of phonatory function in HD was found to parallel increasing motor involvement, a qualitative description of voice dysfunction may be helpful to gain better insight into the pathophysiology of the vocal mechanism.Jan RuszJiří KlempířEva BaborováTereza TykalováVeronika MajerováRoman CmejlaEvžen RůžičkaJan RothPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65881 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan Rusz Jiří Klempíř Eva Baborová Tereza Tykalová Veronika Majerová Roman Cmejla Evžen Růžička Jan Roth Objective acoustic quantification of phonatory dysfunction in Huntington's disease.
description	<h4>Purpose</h4>Although speech motor changes are reported as a common sign of Huntington's disease (HD), the most prominent signs of voice dysfunction remain unknown. The aim of the current study was to explore specific changes in phonatory function in subjects with HD.<h4>Method</h4>34 subjects with HD and 34 age- and sex-matched healthy controls were examined. Participants performed sustained vowel phonation for subsequent analyses of airflow insufficiency, aperiodicity, irregular vibrations of vocal folds, signal perturbations, increased noise, and articulation deficiency. In total, 272 phonations were collected and 12 voice parameters were extracted. Subsequently, a predictive model was built to find the most salient patterns of voice disorders in HD. The results were also correlated with disease severity according to the Unified HD Rating Scale (UHDRS) motor score.<h4>Results</h4>Subjects with HD showed deterioration in all investigated phonatory functions. Irregular pitch fluctuations, sudden phonation interruption, increased noise, and misplacement of articulators were found to be most significant patterns of phonatory dysfunction in HD (p<0.001). The combination of these four dysphonia aspects contributed to the best classification performance of 94.1% (sensitivity: 95.1%; specificity: 93.2%) in the separation of HD patients from healthy participants. Our results further indicated stronger associations between sudden phonation interruption and voluntary components of the UHDRS (r = -0.48, p<0.01) and between misplacement of articulators and involuntary components of the UHDRS (r = 0.52, p<0.01).<h4>Conclusions</h4>Our configuration of phonatory features can detect subtle voice abnormalities in subjects with HD. As impairment of phonatory function in HD was found to parallel increasing motor involvement, a qualitative description of voice dysfunction may be helpful to gain better insight into the pathophysiology of the vocal mechanism.
format	article
author	Jan Rusz Jiří Klempíř Eva Baborová Tereza Tykalová Veronika Majerová Roman Cmejla Evžen Růžička Jan Roth
author_facet	Jan Rusz Jiří Klempíř Eva Baborová Tereza Tykalová Veronika Majerová Roman Cmejla Evžen Růžička Jan Roth
author_sort	Jan Rusz
title	Objective acoustic quantification of phonatory dysfunction in Huntington's disease.
title_short	Objective acoustic quantification of phonatory dysfunction in Huntington's disease.
title_full	Objective acoustic quantification of phonatory dysfunction in Huntington's disease.
title_fullStr	Objective acoustic quantification of phonatory dysfunction in Huntington's disease.
title_full_unstemmed	Objective acoustic quantification of phonatory dysfunction in Huntington's disease.
title_sort	objective acoustic quantification of phonatory dysfunction in huntington's disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ba920f4a00c647ceb46824f577b32936
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Objective acoustic quantification of phonatory dysfunction in Huntington's disease.

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