SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub

SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub

SETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regula...

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Autores principales: Rocco Piazza, Vera Magistroni, Sara Redaelli, Mario Mauri, Luca Massimino, Alessandro Sessa, Marco Peronaci, Maciej Lalowski, Rabah Soliymani, Caterina Mezzatesta, Alessandra Pirola, Federica Banfi, Alicia Rubio, Delphine Rea, Fabio Stagno, Emilio Usala, Bruno Martino, Leonardo Campiotti, Michele Merli, Francesco Passamonti, Francesco Onida, Alessandro Morotti, Francesca Pavesi, Marco Bregni, Vania Broccoli, Marc Baumann, Carlo Gambacorti-Passerini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ba93d3f63f634212b28426582bbfc01b
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spelling oai:doaj.org-article:ba93d3f63f634212b28426582bbfc01b2021-12-02T17:32:48ZSETBP1 induces transcription of a network of development genes by acting as an epigenetic hub10.1038/s41467-018-04462-82041-1723https://doaj.org/article/ba93d3f63f634212b28426582bbfc01b2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04462-8https://doaj.org/toc/2041-1723SETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regulate transcription.Rocco PiazzaVera MagistroniSara RedaelliMario MauriLuca MassiminoAlessandro SessaMarco PeronaciMaciej LalowskiRabah SoliymaniCaterina MezzatestaAlessandra PirolaFederica BanfiAlicia RubioDelphine ReaFabio StagnoEmilio UsalaBruno MartinoLeonardo CampiottiMichele MerliFrancesco PassamontiFrancesco OnidaAlessandro MorottiFrancesca PavesiMarco BregniVania BroccoliMarc BaumannCarlo Gambacorti-PasseriniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rocco Piazza
Vera Magistroni
Sara Redaelli
Mario Mauri
Luca Massimino
Alessandro Sessa
Marco Peronaci
Maciej Lalowski
Rabah Soliymani
Caterina Mezzatesta
Alessandra Pirola
Federica Banfi
Alicia Rubio
Delphine Rea
Fabio Stagno
Emilio Usala
Bruno Martino
Leonardo Campiotti
Michele Merli
Francesco Passamonti
Francesco Onida
Alessandro Morotti
Francesca Pavesi
Marco Bregni
Vania Broccoli
Marc Baumann
Carlo Gambacorti-Passerini
SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
description SETBP1 variants occur as somatic mutations in several malignancies and as de novo germline mutations in developmental disorders. Here the authors provide evidence that SETBP1 binds to gDNA in AT-rich promoter regions to promote target gene upregulation, indicating SETBP1 functions directly to regulate transcription.
format article
author Rocco Piazza
Vera Magistroni
Sara Redaelli
Mario Mauri
Luca Massimino
Alessandro Sessa
Marco Peronaci
Maciej Lalowski
Rabah Soliymani
Caterina Mezzatesta
Alessandra Pirola
Federica Banfi
Alicia Rubio
Delphine Rea
Fabio Stagno
Emilio Usala
Bruno Martino
Leonardo Campiotti
Michele Merli
Francesco Passamonti
Francesco Onida
Alessandro Morotti
Francesca Pavesi
Marco Bregni
Vania Broccoli
Marc Baumann
Carlo Gambacorti-Passerini
author_facet Rocco Piazza
Vera Magistroni
Sara Redaelli
Mario Mauri
Luca Massimino
Alessandro Sessa
Marco Peronaci
Maciej Lalowski
Rabah Soliymani
Caterina Mezzatesta
Alessandra Pirola
Federica Banfi
Alicia Rubio
Delphine Rea
Fabio Stagno
Emilio Usala
Bruno Martino
Leonardo Campiotti
Michele Merli
Francesco Passamonti
Francesco Onida
Alessandro Morotti
Francesca Pavesi
Marco Bregni
Vania Broccoli
Marc Baumann
Carlo Gambacorti-Passerini
author_sort Rocco Piazza
title SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
title_short SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
title_full SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
title_fullStr SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
title_full_unstemmed SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
title_sort setbp1 induces transcription of a network of development genes by acting as an epigenetic hub
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ba93d3f63f634212b28426582bbfc01b
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