Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

The activity of protein tyrosine phosphatase PTP1B, a major metabolic regulator, depends on its oxidation state. Here the authors identify and characterize a small molecule that targets the oxidized, inactive form of PTP1B, suggesting a new therapeutic approach to diabetes and obesity.

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Autores principales:	Navasona Krishnan, Christopher A. Bonham, Ioana A. Rus, Om Kumar Shrestha, Carla M. Gauss, Aftabul Haque, Ante Tocilj, Leemor Joshua-Tor, Nicholas K. Tonks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba9c741928c64ecab9592a1665278839
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spelling	oai:doaj.org-article:ba9c741928c64ecab9592a16652788392021-12-02T16:49:51ZHarnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development10.1038/s41467-017-02252-22041-1723https://doaj.org/article/ba9c741928c64ecab9592a16652788392018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02252-2https://doaj.org/toc/2041-1723The activity of protein tyrosine phosphatase PTP1B, a major metabolic regulator, depends on its oxidation state. Here the authors identify and characterize a small molecule that targets the oxidized, inactive form of PTP1B, suggesting a new therapeutic approach to diabetes and obesity.Navasona KrishnanChristopher A. BonhamIoana A. RusOm Kumar ShresthaCarla M. GaussAftabul HaqueAnte TociljLeemor Joshua-TorNicholas K. TonksNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Navasona Krishnan Christopher A. Bonham Ioana A. Rus Om Kumar Shrestha Carla M. Gauss Aftabul Haque Ante Tocilj Leemor Joshua-Tor Nicholas K. Tonks Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
description	The activity of protein tyrosine phosphatase PTP1B, a major metabolic regulator, depends on its oxidation state. Here the authors identify and characterize a small molecule that targets the oxidized, inactive form of PTP1B, suggesting a new therapeutic approach to diabetes and obesity.
format	article
author	Navasona Krishnan Christopher A. Bonham Ioana A. Rus Om Kumar Shrestha Carla M. Gauss Aftabul Haque Ante Tocilj Leemor Joshua-Tor Nicholas K. Tonks
author_facet	Navasona Krishnan Christopher A. Bonham Ioana A. Rus Om Kumar Shrestha Carla M. Gauss Aftabul Haque Ante Tocilj Leemor Joshua-Tor Nicholas K. Tonks
author_sort	Navasona Krishnan
title	Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
title_short	Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
title_full	Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
title_fullStr	Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
title_full_unstemmed	Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
title_sort	harnessing insulin- and leptin-induced oxidation of ptp1b for therapeutic development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ba9c741928c64ecab9592a1665278839
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Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

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