Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

The activity of protein tyrosine phosphatase PTP1B, a major metabolic regulator, depends on its oxidation state. Here the authors identify and characterize a small molecule that targets the oxidized, inactive form of PTP1B, suggesting a new therapeutic approach to diabetes and obesity.

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Autores principales: Navasona Krishnan, Christopher A. Bonham, Ioana A. Rus, Om Kumar Shrestha, Carla M. Gauss, Aftabul Haque, Ante Tocilj, Leemor Joshua-Tor, Nicholas K. Tonks
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/ba9c741928c64ecab9592a1665278839
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