Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes

Abstract Visual motion perception depends on readout of direction selective sensors. We investigated in mice whether the response to bidirectional transparent motion, activating oppositely tuned sensors, reflects integration (averaging) or winner-take-all (mutual inhibition) mechanisms. We measured...

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Autores principales:	L. A. M. H. Kirkels, W. Zhang, Z. Rezvani, R. J. A. van Wezel, M. M. van Wanrooij
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba9cef6deee14cfaa030409cd54b9bc6
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spelling	oai:doaj.org-article:ba9cef6deee14cfaa030409cd54b9bc62021-12-02T15:45:16ZVisual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes10.1038/s41598-021-89974-y2045-2322https://doaj.org/article/ba9cef6deee14cfaa030409cd54b9bc62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89974-yhttps://doaj.org/toc/2045-2322Abstract Visual motion perception depends on readout of direction selective sensors. We investigated in mice whether the response to bidirectional transparent motion, activating oppositely tuned sensors, reflects integration (averaging) or winner-take-all (mutual inhibition) mechanisms. We measured whole body opto-locomotor reflexes (OLRs) to bidirectional oppositely moving random dot patterns (leftward and rightward) and compared the response to predictions based on responses to unidirectional motion (leftward or rightward). In addition, responses were compared to stimulation with stationary patterns. When comparing OLRs to bidirectional and unidirectional conditions, we found that the OLR to bidirectional motion best fits an averaging model. These results reflect integration mechanisms in neural responses to contradicting sensory evidence as has been documented for other sensory and motor domains.L. A. M. H. KirkelsW. ZhangZ. RezvaniR. J. A. van WezelM. M. van WanrooijNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. A. M. H. Kirkels W. Zhang Z. Rezvani R. J. A. van Wezel M. M. van Wanrooij Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes
description	Abstract Visual motion perception depends on readout of direction selective sensors. We investigated in mice whether the response to bidirectional transparent motion, activating oppositely tuned sensors, reflects integration (averaging) or winner-take-all (mutual inhibition) mechanisms. We measured whole body opto-locomotor reflexes (OLRs) to bidirectional oppositely moving random dot patterns (leftward and rightward) and compared the response to predictions based on responses to unidirectional motion (leftward or rightward). In addition, responses were compared to stimulation with stationary patterns. When comparing OLRs to bidirectional and unidirectional conditions, we found that the OLR to bidirectional motion best fits an averaging model. These results reflect integration mechanisms in neural responses to contradicting sensory evidence as has been documented for other sensory and motor domains.
format	article
author	L. A. M. H. Kirkels W. Zhang Z. Rezvani R. J. A. van Wezel M. M. van Wanrooij
author_facet	L. A. M. H. Kirkels W. Zhang Z. Rezvani R. J. A. van Wezel M. M. van Wanrooij
author_sort	L. A. M. H. Kirkels
title	Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes
title_short	Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes
title_full	Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes
title_fullStr	Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes
title_full_unstemmed	Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes
title_sort	visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ba9cef6deee14cfaa030409cd54b9bc6
work_keys_str_mv	AT lamhkirkels visualmotionintegrationofbidirectionaltransparentmotioninmouseoptolocomotorreflexes AT wzhang visualmotionintegrationofbidirectionaltransparentmotioninmouseoptolocomotorreflexes AT zrezvani visualmotionintegrationofbidirectionaltransparentmotioninmouseoptolocomotorreflexes AT rjavanwezel visualmotionintegrationofbidirectionaltransparentmotioninmouseoptolocomotorreflexes AT mmvanwanrooij visualmotionintegrationofbidirectionaltransparentmotioninmouseoptolocomotorreflexes
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Visual motion integration of bidirectional transparent motion in mouse opto-locomotor reflexes

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