Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.

Past investigations utilizing diffusion tensor imaging (DTI) have demonstrated that cocaine use disorder (CUD) yields white matter changes, primarily in the corpus callosum. By applying Bayesian model averaging using multiple linear regression in DTI, we demonstrate there may exist relationships bet...

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Autores principales:	Tmader Alballa, Edward L Boone, Liangsuo Ma, Andrew Snyder, F Gerard Moeller
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ba9e5ee271b04c738795e9a340b110d0
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id	oai:doaj.org-article:ba9e5ee271b04c738795e9a340b110d0
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spelling	oai:doaj.org-article:ba9e5ee271b04c738795e9a340b110d02021-12-02T20:04:51ZExploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.1932-620310.1371/journal.pone.0254776https://doaj.org/article/ba9e5ee271b04c738795e9a340b110d02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254776https://doaj.org/toc/1932-6203Past investigations utilizing diffusion tensor imaging (DTI) have demonstrated that cocaine use disorder (CUD) yields white matter changes, primarily in the corpus callosum. By applying Bayesian model averaging using multiple linear regression in DTI, we demonstrate there may exist relationships between the impaired white matter and glutamic acid decarboxylase (GAD) polymorphisms. This work explored the two-way and three-way interactions between GAD1a (SNP: rs1978340) and GAD1b (SNP: rs769390) polymorphisms and years of cocaine use (YCU). GAD1a was associated with more frontal white matter changes on its own but GAD1b was associated with more midbrain and cerebellar changes as well as a greater increase in white matter changes in the context of chronic cocaine use. The three-way interaction GAD1a\|GAD1b\|YCU appeared to be roughly an average of the polymorphism two-way interactions GAD1a\|YCU and GAD1b\|YCU. The three-way interaction demonstrated multiple regions including corpus callosum which featured fewer significant voxel changes, perhaps suggesting a small protective effect of having both polymorphisms on corpus callosum and cerebellar peduncle.Tmader AlballaEdward L BooneLiangsuo MaAndrew SnyderF Gerard MoellerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254776 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tmader Alballa Edward L Boone Liangsuo Ma Andrew Snyder F Gerard Moeller Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
description	Past investigations utilizing diffusion tensor imaging (DTI) have demonstrated that cocaine use disorder (CUD) yields white matter changes, primarily in the corpus callosum. By applying Bayesian model averaging using multiple linear regression in DTI, we demonstrate there may exist relationships between the impaired white matter and glutamic acid decarboxylase (GAD) polymorphisms. This work explored the two-way and three-way interactions between GAD1a (SNP: rs1978340) and GAD1b (SNP: rs769390) polymorphisms and years of cocaine use (YCU). GAD1a was associated with more frontal white matter changes on its own but GAD1b was associated with more midbrain and cerebellar changes as well as a greater increase in white matter changes in the context of chronic cocaine use. The three-way interaction GAD1a\|GAD1b\|YCU appeared to be roughly an average of the polymorphism two-way interactions GAD1a\|YCU and GAD1b\|YCU. The three-way interaction demonstrated multiple regions including corpus callosum which featured fewer significant voxel changes, perhaps suggesting a small protective effect of having both polymorphisms on corpus callosum and cerebellar peduncle.
format	article
author	Tmader Alballa Edward L Boone Liangsuo Ma Andrew Snyder F Gerard Moeller
author_facet	Tmader Alballa Edward L Boone Liangsuo Ma Andrew Snyder F Gerard Moeller
author_sort	Tmader Alballa
title	Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
title_short	Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
title_full	Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
title_fullStr	Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
title_full_unstemmed	Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
title_sort	exploring the relationship between white matter integrity, cocaine use and gad polymorphisms using bayesian model averaging.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ba9e5ee271b04c738795e9a340b110d0
work_keys_str_mv	AT tmaderalballa exploringtherelationshipbetweenwhitematterintegritycocaineuseandgadpolymorphismsusingbayesianmodelaveraging AT edwardlboone exploringtherelationshipbetweenwhitematterintegritycocaineuseandgadpolymorphismsusingbayesianmodelaveraging AT liangsuoma exploringtherelationshipbetweenwhitematterintegritycocaineuseandgadpolymorphismsusingbayesianmodelaveraging AT andrewsnyder exploringtherelationshipbetweenwhitematterintegritycocaineuseandgadpolymorphismsusingbayesianmodelaveraging AT fgerardmoeller exploringtherelationshipbetweenwhitematterintegritycocaineuseandgadpolymorphismsusingbayesianmodelaveraging
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Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.

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