Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner.

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Autores principales: Hayden Weng Siong Tan, Arthur Yi Loong Sim, Yun Chau Long
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/baa64e48583c47e993cde6f66f813394
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spelling oai:doaj.org-article:baa64e48583c47e993cde6f66f8133942021-12-02T14:41:09ZGlutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation10.1038/s41467-017-00369-y2041-1723https://doaj.org/article/baa64e48583c47e993cde6f66f8133942017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00369-yhttps://doaj.org/toc/2041-1723mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner.Hayden Weng Siong TanArthur Yi Loong SimYun Chau LongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hayden Weng Siong Tan
Arthur Yi Loong Sim
Yun Chau Long
Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
description mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner.
format article
author Hayden Weng Siong Tan
Arthur Yi Loong Sim
Yun Chau Long
author_facet Hayden Weng Siong Tan
Arthur Yi Loong Sim
Yun Chau Long
author_sort Hayden Weng Siong Tan
title Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
title_short Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
title_full Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
title_fullStr Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
title_full_unstemmed Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
title_sort glutamine metabolism regulates autophagy-dependent mtorc1 reactivation during amino acid starvation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/baa64e48583c47e993cde6f66f813394
work_keys_str_mv AT haydenwengsiongtan glutaminemetabolismregulatesautophagydependentmtorc1reactivationduringaminoacidstarvation
AT arthuryiloongsim glutaminemetabolismregulatesautophagydependentmtorc1reactivationduringaminoacidstarvation
AT yunchaulong glutaminemetabolismregulatesautophagydependentmtorc1reactivationduringaminoacidstarvation
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