Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment

Cell-based drug delivery systems have shown tremendous advantages in cancer treatment due to their distinctive properties. For instance, delivery of therapeutics using tumor-tropic cells like neutrophils, lymphocytes and mesenchymal stem cells can achieve specific tumor targeting due to the “Trojan...

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Autores principales:	Lu Tang, Shun He, Yue Yin, Hening Liu, Jingyi Hu, Jie Cheng, Wei Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cell therapy biomimetic strategy nanomaterial cancer treatment targeted drug delivery Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/baa74733561f4d89b00d8e97d69f8a9e
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spelling	oai:doaj.org-article:baa74733561f4d89b00d8e97d69f8a9e2021-11-25T18:41:31ZCombination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment10.3390/pharmaceutics131118881999-4923https://doaj.org/article/baa74733561f4d89b00d8e97d69f8a9e2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1888https://doaj.org/toc/1999-4923Cell-based drug delivery systems have shown tremendous advantages in cancer treatment due to their distinctive properties. For instance, delivery of therapeutics using tumor-tropic cells like neutrophils, lymphocytes and mesenchymal stem cells can achieve specific tumor targeting due to the “Trojan Horse” effect. Other circulatory cells like erythrocytes and platelets can greatly improve the circulation time of nanoparticles due to their innate long circulation property. Adipocytes, especially cancer-associated adipocytes, play key roles in tumor development and metabolism, therefore, adipocytes are regarded as promising bio-derived nanoplatforms for anticancer targeted drug delivery. Nanomaterials are important participants in cell-based drug delivery because of their unique physicochemical characteristics. Therefore, the integration of various nanomaterials with different cell types will endow the constructed delivery systems with many attractive properties due to the merits of both. In this review, a number of strategies based on nanomaterial-involved cell-mediated drug delivery systems for cancer treatment will be summarized. This review discusses how nanomaterials can be a benefit to cell-based therapies and how cell-derived carriers overcome the limitations of nanomaterials, which highlights recent advancements and specific biomedical applications based on nanomaterial-mediated, cell-based drug delivery systems.Lu TangShun HeYue YinHening LiuJingyi HuJie ChengWei WangMDPI AGarticlecell therapybiomimetic strategynanomaterialcancer treatmenttargeted drug deliveryPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1888, p 1888 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell therapy biomimetic strategy nanomaterial cancer treatment targeted drug delivery Pharmacy and materia medica RS1-441
spellingShingle	cell therapy biomimetic strategy nanomaterial cancer treatment targeted drug delivery Pharmacy and materia medica RS1-441 Lu Tang Shun He Yue Yin Hening Liu Jingyi Hu Jie Cheng Wei Wang Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment
description	Cell-based drug delivery systems have shown tremendous advantages in cancer treatment due to their distinctive properties. For instance, delivery of therapeutics using tumor-tropic cells like neutrophils, lymphocytes and mesenchymal stem cells can achieve specific tumor targeting due to the “Trojan Horse” effect. Other circulatory cells like erythrocytes and platelets can greatly improve the circulation time of nanoparticles due to their innate long circulation property. Adipocytes, especially cancer-associated adipocytes, play key roles in tumor development and metabolism, therefore, adipocytes are regarded as promising bio-derived nanoplatforms for anticancer targeted drug delivery. Nanomaterials are important participants in cell-based drug delivery because of their unique physicochemical characteristics. Therefore, the integration of various nanomaterials with different cell types will endow the constructed delivery systems with many attractive properties due to the merits of both. In this review, a number of strategies based on nanomaterial-involved cell-mediated drug delivery systems for cancer treatment will be summarized. This review discusses how nanomaterials can be a benefit to cell-based therapies and how cell-derived carriers overcome the limitations of nanomaterials, which highlights recent advancements and specific biomedical applications based on nanomaterial-mediated, cell-based drug delivery systems.
format	article
author	Lu Tang Shun He Yue Yin Hening Liu Jingyi Hu Jie Cheng Wei Wang
author_facet	Lu Tang Shun He Yue Yin Hening Liu Jingyi Hu Jie Cheng Wei Wang
author_sort	Lu Tang
title	Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment
title_short	Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment
title_full	Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment
title_fullStr	Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment
title_full_unstemmed	Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment
title_sort	combination of nanomaterials in cell-based drug delivery systems for cancer treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/baa74733561f4d89b00d8e97d69f8a9e
work_keys_str_mv	AT lutang combinationofnanomaterialsincellbaseddrugdeliverysystemsforcancertreatment AT shunhe combinationofnanomaterialsincellbaseddrugdeliverysystemsforcancertreatment AT yueyin combinationofnanomaterialsincellbaseddrugdeliverysystemsforcancertreatment AT heningliu combinationofnanomaterialsincellbaseddrugdeliverysystemsforcancertreatment AT jingyihu combinationofnanomaterialsincellbaseddrugdeliverysystemsforcancertreatment AT jiecheng combinationofnanomaterialsincellbaseddrugdeliverysystemsforcancertreatment AT weiwang combinationofnanomaterialsincellbaseddrugdeliverysystemsforcancertreatment
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Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment

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