The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.

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Autores principales: Carla F. Bento, Avraham Ashkenazi, Maria Jimenez-Sanchez, David C. Rubinsztein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb850
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spelling oai:doaj.org-article:baacf41cfdf54bc0bef63a27d2ffb8502021-12-02T17:33:21ZThe Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway10.1038/ncomms118032041-1723https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb8502016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11803https://doaj.org/toc/2041-1723Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.Carla F. BentoAvraham AshkenaziMaria Jimenez-SanchezDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Carla F. Bento
Avraham Ashkenazi
Maria Jimenez-Sanchez
David C. Rubinsztein
The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
description Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.
format article
author Carla F. Bento
Avraham Ashkenazi
Maria Jimenez-Sanchez
David C. Rubinsztein
author_facet Carla F. Bento
Avraham Ashkenazi
Maria Jimenez-Sanchez
David C. Rubinsztein
author_sort Carla F. Bento
title The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_short The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_full The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_fullStr The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_full_unstemmed The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_sort parkinson’s disease-associated genes atp13a2 and syt11 regulate autophagy via a common pathway
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb850
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