The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.
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Nature Portfolio
2016
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oai:doaj.org-article:baacf41cfdf54bc0bef63a27d2ffb8502021-12-02T17:33:21ZThe Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway10.1038/ncomms118032041-1723https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb8502016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11803https://doaj.org/toc/2041-1723Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.Carla F. BentoAvraham AshkenaziMaria Jimenez-SanchezDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
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Science Q Carla F. Bento Avraham Ashkenazi Maria Jimenez-Sanchez David C. Rubinsztein The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway |
description |
Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway. |
format |
article |
author |
Carla F. Bento Avraham Ashkenazi Maria Jimenez-Sanchez David C. Rubinsztein |
author_facet |
Carla F. Bento Avraham Ashkenazi Maria Jimenez-Sanchez David C. Rubinsztein |
author_sort |
Carla F. Bento |
title |
The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway |
title_short |
The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway |
title_full |
The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway |
title_fullStr |
The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway |
title_full_unstemmed |
The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway |
title_sort |
parkinson’s disease-associated genes atp13a2 and syt11 regulate autophagy via a common pathway |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb850 |
work_keys_str_mv |
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