The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.

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Main Authors:	Carla F. Bento, Avraham Ashkenazi, Maria Jimenez-Sanchez, David C. Rubinsztein
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb850
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spelling	oai:doaj.org-article:baacf41cfdf54bc0bef63a27d2ffb8502021-12-02T17:33:21ZThe Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway10.1038/ncomms118032041-1723https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb8502016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11803https://doaj.org/toc/2041-1723Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.Carla F. BentoAvraham AshkenaziMaria Jimenez-SanchezDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carla F. Bento Avraham Ashkenazi Maria Jimenez-Sanchez David C. Rubinsztein The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
description	Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway.
format	article
author	Carla F. Bento Avraham Ashkenazi Maria Jimenez-Sanchez David C. Rubinsztein
author_facet	Carla F. Bento Avraham Ashkenazi Maria Jimenez-Sanchez David C. Rubinsztein
author_sort	Carla F. Bento
title	The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_short	The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_full	The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_fullStr	The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_full_unstemmed	The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
title_sort	parkinson’s disease-associated genes atp13a2 and syt11 regulate autophagy via a common pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/baacf41cfdf54bc0bef63a27d2ffb850
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The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

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