A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study

Abstract Although several risk factors for the onset of pancreatic ductal adenocarcinoma (PDAC) have been identified, currently, no scoring system to systemically evaluate the risk of PDAC has been established. In this study, we aimed to use a population of over 1200 patients to build a novel scorin...

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Autores principales:	Tianshu Pang, Guoping Ding, Zhengrong Wu, Guixing Jiang, Yifei Yang, Xiaofei Zhang, Liping Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/baad1152e5a343f087b042df5b4e4b44
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spelling	oai:doaj.org-article:baad1152e5a343f087b042df5b4e4b442021-12-02T15:06:08ZA novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study10.1038/s41598-017-13182-w2045-2322https://doaj.org/article/baad1152e5a343f087b042df5b4e4b442017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-13182-whttps://doaj.org/toc/2045-2322Abstract Although several risk factors for the onset of pancreatic ductal adenocarcinoma (PDAC) have been identified, currently, no scoring system to systemically evaluate the risk of PDAC has been established. In this study, we aimed to use a population of over 1200 patients to build a novel scoring system, and evaluated combined effects of risk factors for PDAC patients.A set of 4904 participants including 1274 PDAC patients and 3630 non-cancer individuals were recruited for the single-center study over 17-year period (1997~2013). Systematic logical analysis were presented for case and control groups, and a risk rating system was constructed to assess combined risk factors. Seven independent risk factors were identified with the increased risk of PDAC, were selected into the risk score. A merged risk assessment model was established, demonstrating significantly increased PDAC risk in following a number of rising scores. Individuals with scores from 1 to more than 4, the responding OR (95% CI) were 3.06 (2.57~3.65), 7.08 (5.63~8.91), 22.4 (14.2~35.4), and 31.4 (12.7~77.5), respectively. The integer-based risk score in the study can be used for risk stratification to accurately evaluate PDAC occurrence at an early stage. This scoring system provides an accurate risk assessment of PDAC risk.Tianshu PangGuoping DingZhengrong WuGuixing JiangYifei YangXiaofei ZhangLiping CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tianshu Pang Guoping Ding Zhengrong Wu Guixing Jiang Yifei Yang Xiaofei Zhang Liping Cao A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study
description	Abstract Although several risk factors for the onset of pancreatic ductal adenocarcinoma (PDAC) have been identified, currently, no scoring system to systemically evaluate the risk of PDAC has been established. In this study, we aimed to use a population of over 1200 patients to build a novel scoring system, and evaluated combined effects of risk factors for PDAC patients.A set of 4904 participants including 1274 PDAC patients and 3630 non-cancer individuals were recruited for the single-center study over 17-year period (1997~2013). Systematic logical analysis were presented for case and control groups, and a risk rating system was constructed to assess combined risk factors. Seven independent risk factors were identified with the increased risk of PDAC, were selected into the risk score. A merged risk assessment model was established, demonstrating significantly increased PDAC risk in following a number of rising scores. Individuals with scores from 1 to more than 4, the responding OR (95% CI) were 3.06 (2.57~3.65), 7.08 (5.63~8.91), 22.4 (14.2~35.4), and 31.4 (12.7~77.5), respectively. The integer-based risk score in the study can be used for risk stratification to accurately evaluate PDAC occurrence at an early stage. This scoring system provides an accurate risk assessment of PDAC risk.
format	article
author	Tianshu Pang Guoping Ding Zhengrong Wu Guixing Jiang Yifei Yang Xiaofei Zhang Liping Cao
author_facet	Tianshu Pang Guoping Ding Zhengrong Wu Guixing Jiang Yifei Yang Xiaofei Zhang Liping Cao
author_sort	Tianshu Pang
title	A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study
title_short	A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study
title_full	A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study
title_fullStr	A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study
title_full_unstemmed	A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study
title_sort	novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/baad1152e5a343f087b042df5b4e4b44
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A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study

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