Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks

Abstract TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into m...

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Autores principales:	Michael Ansorge, Jiranuwat Sapudom, Marina Chkolnikov, Martin Wilde, Ulf Anderegg, Stephanie Möller, Matthias Schnabelrauch, Tilo Pompe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/baad139bac064aadbbfd8a92a35b03b7
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spelling	oai:doaj.org-article:baad139bac064aadbbfd8a92a35b03b72021-12-02T16:07:59ZMimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks10.1038/s41598-017-05912-x2045-2322https://doaj.org/article/baad139bac064aadbbfd8a92a35b03b72017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05912-xhttps://doaj.org/toc/2045-2322Abstract TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.Michael AnsorgeJiranuwat SapudomMarina ChkolnikovMartin WildeUlf AndereggStephanie MöllerMatthias SchnabelrauchTilo PompeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Ansorge Jiranuwat Sapudom Marina Chkolnikov Martin Wilde Ulf Anderegg Stephanie Möller Matthias Schnabelrauch Tilo Pompe Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks
description	Abstract TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.
format	article
author	Michael Ansorge Jiranuwat Sapudom Marina Chkolnikov Martin Wilde Ulf Anderegg Stephanie Möller Matthias Schnabelrauch Tilo Pompe
author_facet	Michael Ansorge Jiranuwat Sapudom Marina Chkolnikov Martin Wilde Ulf Anderegg Stephanie Möller Matthias Schnabelrauch Tilo Pompe
author_sort	Michael Ansorge
title	Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks
title_short	Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks
title_full	Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks
title_fullStr	Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks
title_full_unstemmed	Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks
title_sort	mimicking paracrine tgfβ1 signals during myofibroblast differentiation in 3d collagen networks
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/baad139bac064aadbbfd8a92a35b03b7
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Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks

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