Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks

Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks

Abstract TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into m...

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Bibliographic Details
Main Authors: Michael Ansorge, Jiranuwat Sapudom, Marina Chkolnikov, Martin Wilde, Ulf Anderegg, Stephanie Möller, Matthias Schnabelrauch, Tilo Pompe
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/baad139bac064aadbbfd8a92a35b03b7
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