Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ.
A definitive consequence of the aging process is the progressive deterioration of higher cognitive functions. Defects in DNA repair mechanisms mostly result in accelerated aging and reduced brain function. DNA polymerase µ is a novel accessory partner for the non-homologous end-joining DNA repair pa...
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2013
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oai:doaj.org-article:baadea94e7b84ecfb2e8151ccb7d34e72021-11-18T08:02:46ZIncreased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ.1932-620310.1371/journal.pone.0053243https://doaj.org/article/baadea94e7b84ecfb2e8151ccb7d34e72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23301049/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A definitive consequence of the aging process is the progressive deterioration of higher cognitive functions. Defects in DNA repair mechanisms mostly result in accelerated aging and reduced brain function. DNA polymerase µ is a novel accessory partner for the non-homologous end-joining DNA repair pathway for double-strand breaks, and its deficiency causes reduced DNA repair. Using associative learning and long-term potentiation experiments, we demonstrate that Polµ(-/-) mice, however, maintain the ability to learn at ages when wild-type mice do not. Expression and biochemical analyses suggest that brain aging is delayed in Polµ(-/-) mice, being associated with a reduced error-prone DNA oxidative repair activity and a more efficient mitochondrial function. This is the first example in which the genetic ablation of a DNA-repair function results in a substantially better maintenance of learning abilities, together with fewer signs of brain aging, in old mice.Daniel LucasJosé M Delgado-GarcíaBeatriz EscuderoCarmen AlboAna AzaRebeca Acín-PérezYaima TorresPaz MorenoJosé Antonio EnríquezEnrique SamperLuis BlancoAlfonso FairénAntonio BernadAgnès GruartPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53243 (2013) |
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DOAJ |
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| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Daniel Lucas José M Delgado-García Beatriz Escudero Carmen Albo Ana Aza Rebeca Acín-Pérez Yaima Torres Paz Moreno José Antonio Enríquez Enrique Samper Luis Blanco Alfonso Fairén Antonio Bernad Agnès Gruart Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ. |
| description |
A definitive consequence of the aging process is the progressive deterioration of higher cognitive functions. Defects in DNA repair mechanisms mostly result in accelerated aging and reduced brain function. DNA polymerase µ is a novel accessory partner for the non-homologous end-joining DNA repair pathway for double-strand breaks, and its deficiency causes reduced DNA repair. Using associative learning and long-term potentiation experiments, we demonstrate that Polµ(-/-) mice, however, maintain the ability to learn at ages when wild-type mice do not. Expression and biochemical analyses suggest that brain aging is delayed in Polµ(-/-) mice, being associated with a reduced error-prone DNA oxidative repair activity and a more efficient mitochondrial function. This is the first example in which the genetic ablation of a DNA-repair function results in a substantially better maintenance of learning abilities, together with fewer signs of brain aging, in old mice. |
| format |
article |
| author |
Daniel Lucas José M Delgado-García Beatriz Escudero Carmen Albo Ana Aza Rebeca Acín-Pérez Yaima Torres Paz Moreno José Antonio Enríquez Enrique Samper Luis Blanco Alfonso Fairén Antonio Bernad Agnès Gruart |
| author_facet |
Daniel Lucas José M Delgado-García Beatriz Escudero Carmen Albo Ana Aza Rebeca Acín-Pérez Yaima Torres Paz Moreno José Antonio Enríquez Enrique Samper Luis Blanco Alfonso Fairén Antonio Bernad Agnès Gruart |
| author_sort |
Daniel Lucas |
| title |
Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ. |
| title_short |
Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ. |
| title_full |
Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ. |
| title_fullStr |
Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ. |
| title_full_unstemmed |
Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ. |
| title_sort |
increased learning and brain long-term potentiation in aged mice lacking dna polymerase μ. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/baadea94e7b84ecfb2e8151ccb7d34e7 |
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