Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy
Background: Thulium laser resection of bladder tumors (TmLRBT) is recently considered as a common treatment option for non-muscle-invasive bladder cancers (NMIBC), but whether it is superior to Transurethral resection of bladder tumors (TURBT) are still undetermined.Materials and Methods: We retrosp...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:bab02b686df941cb9b9d4cd4932bedb62021-11-08T07:48:11ZThulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy2296-875X10.3389/fsurg.2021.759487https://doaj.org/article/bab02b686df941cb9b9d4cd4932bedb62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.759487/fullhttps://doaj.org/toc/2296-875XBackground: Thulium laser resection of bladder tumors (TmLRBT) is recently considered as a common treatment option for non-muscle-invasive bladder cancers (NMIBC), but whether it is superior to Transurethral resection of bladder tumors (TURBT) are still undetermined.Materials and Methods: We retrospectively screened our institution database to identify patients who were treated by conventional TURBT or TmLRBT for NMIBC and followed by intravesical bacillus Calmette-Guérin (BCG) immunotherapy. The preoperative characteristics, perioperative outcomes, and recurrence-free survival were compared to assess the safety and efficacy of the two procedures.Results: Eventually, 90 patients who underwent TmLRBT (n = 37) or TURBT (n = 53) followed by intravesical BCG immunotherapy were included. Two groups were similar in baseline characteristics except for the smaller tumor size of the TmLRBT group(1.7 cm vs. 2.2 cm; P = 0.036). Obturator nerve reflex occurred in eight patients in the TURBT group and 3 of them suffered from bladder perforation while none happened in the TmLRBT group. The TmLRBT also had a shorter irrigation duration. In the multivariate Cox regression, the TmLRBT was related to less recurrence risk (HR: 0.268; 95% CI, 0.095–0.759; P = 0.013).Conclusion: Our results suggested that TmLRBT is safer than conventional TURBT with fewer perioperative complications, and it offers better cancer control, therefore might be a superior option for NMIBC patients with intermediate and high recurrence risk.Zheng LiuZheng LiuGongwei LongGongwei LongYucong ZhangYucong ZhangYucong ZhangGuoliang SunGuoliang SunWei OuyangWei OuyangShen WangShen WangHao XuHao XuZhihua WangZhihua WangWei GuanWei GuanXiao YuXiao YuZhiquan HuZhiquan HuZhong ChenZhong ChenShaogang WangShaogang WangHeng LiHeng LiFrontiers Media S.A.articlethulium laseren bloc resection of bladder tumornon-muscle-invasive bladder cancerbacillus Calmette-Guérin vaccinetransurethral resection of bladder tumorsSurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021) |
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thulium laser en bloc resection of bladder tumor non-muscle-invasive bladder cancer bacillus Calmette-Guérin vaccine transurethral resection of bladder tumors Surgery RD1-811 |
| spellingShingle |
thulium laser en bloc resection of bladder tumor non-muscle-invasive bladder cancer bacillus Calmette-Guérin vaccine transurethral resection of bladder tumors Surgery RD1-811 Zheng Liu Zheng Liu Gongwei Long Gongwei Long Yucong Zhang Yucong Zhang Yucong Zhang Guoliang Sun Guoliang Sun Wei Ouyang Wei Ouyang Shen Wang Shen Wang Hao Xu Hao Xu Zhihua Wang Zhihua Wang Wei Guan Wei Guan Xiao Yu Xiao Yu Zhiquan Hu Zhiquan Hu Zhong Chen Zhong Chen Shaogang Wang Shaogang Wang Heng Li Heng Li Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy |
| description |
Background: Thulium laser resection of bladder tumors (TmLRBT) is recently considered as a common treatment option for non-muscle-invasive bladder cancers (NMIBC), but whether it is superior to Transurethral resection of bladder tumors (TURBT) are still undetermined.Materials and Methods: We retrospectively screened our institution database to identify patients who were treated by conventional TURBT or TmLRBT for NMIBC and followed by intravesical bacillus Calmette-Guérin (BCG) immunotherapy. The preoperative characteristics, perioperative outcomes, and recurrence-free survival were compared to assess the safety and efficacy of the two procedures.Results: Eventually, 90 patients who underwent TmLRBT (n = 37) or TURBT (n = 53) followed by intravesical BCG immunotherapy were included. Two groups were similar in baseline characteristics except for the smaller tumor size of the TmLRBT group(1.7 cm vs. 2.2 cm; P = 0.036). Obturator nerve reflex occurred in eight patients in the TURBT group and 3 of them suffered from bladder perforation while none happened in the TmLRBT group. The TmLRBT also had a shorter irrigation duration. In the multivariate Cox regression, the TmLRBT was related to less recurrence risk (HR: 0.268; 95% CI, 0.095–0.759; P = 0.013).Conclusion: Our results suggested that TmLRBT is safer than conventional TURBT with fewer perioperative complications, and it offers better cancer control, therefore might be a superior option for NMIBC patients with intermediate and high recurrence risk. |
| format |
article |
| author |
Zheng Liu Zheng Liu Gongwei Long Gongwei Long Yucong Zhang Yucong Zhang Yucong Zhang Guoliang Sun Guoliang Sun Wei Ouyang Wei Ouyang Shen Wang Shen Wang Hao Xu Hao Xu Zhihua Wang Zhihua Wang Wei Guan Wei Guan Xiao Yu Xiao Yu Zhiquan Hu Zhiquan Hu Zhong Chen Zhong Chen Shaogang Wang Shaogang Wang Heng Li Heng Li |
| author_facet |
Zheng Liu Zheng Liu Gongwei Long Gongwei Long Yucong Zhang Yucong Zhang Yucong Zhang Guoliang Sun Guoliang Sun Wei Ouyang Wei Ouyang Shen Wang Shen Wang Hao Xu Hao Xu Zhihua Wang Zhihua Wang Wei Guan Wei Guan Xiao Yu Xiao Yu Zhiquan Hu Zhiquan Hu Zhong Chen Zhong Chen Shaogang Wang Shaogang Wang Heng Li Heng Li |
| author_sort |
Zheng Liu |
| title |
Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy |
| title_short |
Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy |
| title_full |
Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy |
| title_fullStr |
Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy |
| title_full_unstemmed |
Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy |
| title_sort |
thulium laser resection of bladder tumors vs. conventional transurethral resection of bladder tumors for intermediate and high risk non-muscle-invasive bladder cancer followed by intravesical bcg immunotherapy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/bab02b686df941cb9b9d4cd4932bedb6 |
| work_keys_str_mv |
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