Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder

Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder

D Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A LucacchiniDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, ItalyAbstract: Alt...

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Autores principales: D Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A Lucacchini
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2009
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/bab05ae95e244b45beae604d291c22e6
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spelling oai:doaj.org-article:bab05ae95e244b45beae604d291c22e62021-12-02T02:33:43ZAdenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder1176-63281178-2021https://doaj.org/article/bab05ae95e244b45beae604d291c22e62009-07-01T00:00:00Zhttp://www.dovepress.com/adenylate-cyclase-activity-in-platelets-of-patients-with-obsessive-com-a3318https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021D Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A LucacchiniDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, ItalyAbstract: Although the main biological hypothesis on the pathophysiology of obsessive-compulsive disorder (OCD) is centered on the serotonin system, indications are available that other neurotransmitters, and even second messengers, particularly the cyclic adenosine monophosphate (cAMP) signaling, may be involved, though effective data are few. Therefore, the aim of the present study was to evaluate and compare the basal and isoprenaline (ISO)-stimulated velocity of adenylate-cyclase (AC) in human platelet membranes of patients with OCD and healthy control subjects. The results showed that the basal and ISO-stimulated AC activity, as well as the dose-response curves of ISO by using agonist concentrations ranging between 0.1 nM and 10 µM, were not different in the two groups. However, OCD patients showed lower EC50 and higher Emax values than healthy subjects. These findings suggest the presence of supersensitive β-adrenergic receptors in platelets of OCD patients.Keywords: obsessive-compulsive disorder, norepinephrine, second messengers, adenylate-cyclase, platelets, isoprenaline, β-adrenergic receptors D Marazziti, S BaroniL Palego, I Masala, G ConsoliM Catena Dell’Osso, G GiannacciniA LucacchiniDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 363-367 (2009)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
D Marazziti, S Baroni
L Palego, I Masala, G Consoli
M Catena Dell’Osso, G Giannaccini
A Lucacchini
Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
description D Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A LucacchiniDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, ItalyAbstract: Although the main biological hypothesis on the pathophysiology of obsessive-compulsive disorder (OCD) is centered on the serotonin system, indications are available that other neurotransmitters, and even second messengers, particularly the cyclic adenosine monophosphate (cAMP) signaling, may be involved, though effective data are few. Therefore, the aim of the present study was to evaluate and compare the basal and isoprenaline (ISO)-stimulated velocity of adenylate-cyclase (AC) in human platelet membranes of patients with OCD and healthy control subjects. The results showed that the basal and ISO-stimulated AC activity, as well as the dose-response curves of ISO by using agonist concentrations ranging between 0.1 nM and 10 µM, were not different in the two groups. However, OCD patients showed lower EC50 and higher Emax values than healthy subjects. These findings suggest the presence of supersensitive β-adrenergic receptors in platelets of OCD patients.Keywords: obsessive-compulsive disorder, norepinephrine, second messengers, adenylate-cyclase, platelets, isoprenaline, β-adrenergic receptors
format article
author D Marazziti, S Baroni
L Palego, I Masala, G Consoli
M Catena Dell’Osso, G Giannaccini
A Lucacchini
author_facet D Marazziti, S Baroni
L Palego, I Masala, G Consoli
M Catena Dell’Osso, G Giannaccini
A Lucacchini
author_sort D Marazziti, S Baroni
title Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
title_short Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
title_full Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
title_fullStr Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
title_full_unstemmed Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
title_sort adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
publisher Dove Medical Press
publishDate 2009
url https://doaj.org/article/bab05ae95e244b45beae604d291c22e6
work_keys_str_mv AT dmarazzitiampnbspsbaroni adenylatecyclaseactivityinplateletsofpatientswithobsessivecompulsivedisorder
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AT mcatenadellamprsquoossoampnbspggiannaccini adenylatecyclaseactivityinplateletsofpatientswithobsessivecompulsivedisorder
AT alucacchini adenylatecyclaseactivityinplateletsofpatientswithobsessivecompulsivedisorder
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