The mechanical response of talin

Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function as a force buffer under physiologically relevan...

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Autores principales:	Mingxi Yao, Benjamin T. Goult, Benjamin Klapholz, Xian Hu, Christopher P. Toseland, Yingjian Guo, Peiwen Cong, Michael P. Sheetz, Jie Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bab088eae21c4aa09d879414bfbc9a59
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id	oai:doaj.org-article:bab088eae21c4aa09d879414bfbc9a59
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spelling	oai:doaj.org-article:bab088eae21c4aa09d879414bfbc9a592021-12-02T16:58:12ZThe mechanical response of talin10.1038/ncomms119662041-1723https://doaj.org/article/bab088eae21c4aa09d879414bfbc9a592016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms11966https://doaj.org/toc/2041-1723Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function as a force buffer under physiologically relevant conditions.Mingxi YaoBenjamin T. GoultBenjamin KlapholzXian HuChristopher P. ToselandYingjian GuoPeiwen CongMichael P. SheetzJie YanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingxi Yao Benjamin T. Goult Benjamin Klapholz Xian Hu Christopher P. Toseland Yingjian Guo Peiwen Cong Michael P. Sheetz Jie Yan The mechanical response of talin
description	Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function as a force buffer under physiologically relevant conditions.
format	article
author	Mingxi Yao Benjamin T. Goult Benjamin Klapholz Xian Hu Christopher P. Toseland Yingjian Guo Peiwen Cong Michael P. Sheetz Jie Yan
author_facet	Mingxi Yao Benjamin T. Goult Benjamin Klapholz Xian Hu Christopher P. Toseland Yingjian Guo Peiwen Cong Michael P. Sheetz Jie Yan
author_sort	Mingxi Yao
title	The mechanical response of talin
title_short	The mechanical response of talin
title_full	The mechanical response of talin
title_fullStr	The mechanical response of talin
title_full_unstemmed	The mechanical response of talin
title_sort	mechanical response of talin
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bab088eae21c4aa09d879414bfbc9a59
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The mechanical response of talin

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