Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study.
<h4>Objectives</h4>We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention.<h4>Population and me...
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oai:doaj.org-article:bab7024e2c754d1c86ae22bfb403f69c2021-11-18T08:08:52ZProspective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study.1932-620310.1371/journal.pone.0048876https://doaj.org/article/bab7024e2c754d1c86ae22bfb403f69c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23155422/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention.<h4>Population and methods</h4>A cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1.<h4>Results</h4>At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all p<0.001) and with a statistically significant increased risk of overweight/obesity. Over the two year follow-up, no interaction between genotype and intervention was observed. The A allele was associated to a significantly higher increase in all the anthropometric variables examined at T0 independently from the study group (intervention versus control) (p-values: all p<0.002, adjusted for age, sex, country, intervention/control study group, T0 values, and individual time interval between T0 and T1). Over the two-year follow-up, 210 new cases of overweight/obesity occurred. A statistically significant higher incidence of overweight/obesity was associated to the A allele [OR(A) = 1.95, 95% CI = (1.29; 2.97)].<h4>Conclusions</h4>We confirmed the association between the FTO rs9939609 and body mass and overweight/obesity risk in European children. The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth, independently from intervention measures.Fabio LauriaAlfonso SianiKarin BammannRonja ForaitaInge HuybrechtsLicia IacovielloAnna C KoniYannis KouridesStaffan MarildDenes MolnarLuis A MorenoIris PigeotYannis P PitsiladisToomas VeidebaumPaola RussoIDEFICS ConsortiumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48876 (2012) |
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Medicine R Science Q Fabio Lauria Alfonso Siani Karin Bammann Ronja Foraita Inge Huybrechts Licia Iacoviello Anna C Koni Yannis Kourides Staffan Marild Denes Molnar Luis A Moreno Iris Pigeot Yannis P Pitsiladis Toomas Veidebaum Paola Russo IDEFICS Consortium Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. |
| description |
<h4>Objectives</h4>We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention.<h4>Population and methods</h4>A cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1.<h4>Results</h4>At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all p<0.001) and with a statistically significant increased risk of overweight/obesity. Over the two year follow-up, no interaction between genotype and intervention was observed. The A allele was associated to a significantly higher increase in all the anthropometric variables examined at T0 independently from the study group (intervention versus control) (p-values: all p<0.002, adjusted for age, sex, country, intervention/control study group, T0 values, and individual time interval between T0 and T1). Over the two-year follow-up, 210 new cases of overweight/obesity occurred. A statistically significant higher incidence of overweight/obesity was associated to the A allele [OR(A) = 1.95, 95% CI = (1.29; 2.97)].<h4>Conclusions</h4>We confirmed the association between the FTO rs9939609 and body mass and overweight/obesity risk in European children. The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth, independently from intervention measures. |
| format |
article |
| author |
Fabio Lauria Alfonso Siani Karin Bammann Ronja Foraita Inge Huybrechts Licia Iacoviello Anna C Koni Yannis Kourides Staffan Marild Denes Molnar Luis A Moreno Iris Pigeot Yannis P Pitsiladis Toomas Veidebaum Paola Russo IDEFICS Consortium |
| author_facet |
Fabio Lauria Alfonso Siani Karin Bammann Ronja Foraita Inge Huybrechts Licia Iacoviello Anna C Koni Yannis Kourides Staffan Marild Denes Molnar Luis A Moreno Iris Pigeot Yannis P Pitsiladis Toomas Veidebaum Paola Russo IDEFICS Consortium |
| author_sort |
Fabio Lauria |
| title |
Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. |
| title_short |
Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. |
| title_full |
Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. |
| title_fullStr |
Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. |
| title_full_unstemmed |
Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. |
| title_sort |
prospective analysis of the association of a common variant of fto (rs9939609) with adiposity in children: results of the idefics study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/bab7024e2c754d1c86ae22bfb403f69c |
| work_keys_str_mv |
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