HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients.
<h4>Background and aims</h4>Hepatic stellate cells, the major producers of extracellular matrix in the liver, and hepatocytes bear CXCR4 and CCR5, the two main co-receptors for entry of the human immunodeficiency virus (HIV). In vitro studies suggest that HIV-envelope proteins can modula...
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Public Library of Science (PLoS)
2012
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oai:doaj.org-article:bab85cd44e4d4f14839ff1476abf71912021-11-18T08:06:54ZHIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients.1932-620310.1371/journal.pone.0050289https://doaj.org/article/bab85cd44e4d4f14839ff1476abf71912012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23226258/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and aims</h4>Hepatic stellate cells, the major producers of extracellular matrix in the liver, and hepatocytes bear CXCR4 and CCR5, the two main co-receptors for entry of the human immunodeficiency virus (HIV). In vitro studies suggest that HIV-envelope proteins can modulate the replication of hepatitis C virus (HCV) and fibrogenesis. We investigated the influence of HIV tropism on liver fibrosis and the concentration of HCV RNA in HIV-HCV co-infected patients.<h4>Methods</h4>We used a phenotypic assay to assess HIV tropism in 172 HCV-HIV co-infected patients: one group (75 patients) had mild fibrosis (score ≤F2) and the other (97 patients) had severe fibrosis (score >F2). We also assessed the relationship between HIV tropism and HCV RNA concentration in all these patients. We also followed 34 of these patients for 3 years to determine the evolution of HIV tropism and liver fibrosis, estimated by liver stiffness.<h4>Results</h4>Initially, most patients (91.8%) received a potent antiretroviral therapy. CXCR4-using viruses were found in 29% of patients. The only factor associated with a CXCR4-using virus infection in multivariate analysis was the nadir of CD4 cells: <200/mm(3) (OR: 3.94, 95%CI: 1.39-11.14). The median HCV RNA concentrations in patients infected with R5 viruses, those with dual-mixed viruses and those with X4 viruses, were all similar. The prevalence of CXCR4-using viruses in patients with mild fibrosis (≤F2) (31%) and those with severe fibrosis (F3-F4) (28%, p = 0.6) was similar. Longitudinal analyses showed that the presence of CXCR4-using viruses did not increase the likelihood of fibrosis progression, evaluated by measuring liver stiffness.<h4>Conclusions</h4>The presence of CXCR4-using viruses in patients receiving a potent antiretroviral therapy does not influence HCV RNA concentration or liver fibrosis.Florence AbravanelStéphanie RaymondElodie PambrunMaria WinnockPhilippe BonnardPhilippe SogniPascale TrimouletFrançois DabisDominique Salmon-CeronJacques IzopetANRS CO13 HEPAVIH Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50289 (2012) |
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| spellingShingle |
Medicine R Science Q Florence Abravanel Stéphanie Raymond Elodie Pambrun Maria Winnock Philippe Bonnard Philippe Sogni Pascale Trimoulet François Dabis Dominique Salmon-Ceron Jacques Izopet ANRS CO13 HEPAVIH Study Group HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients. |
| description |
<h4>Background and aims</h4>Hepatic stellate cells, the major producers of extracellular matrix in the liver, and hepatocytes bear CXCR4 and CCR5, the two main co-receptors for entry of the human immunodeficiency virus (HIV). In vitro studies suggest that HIV-envelope proteins can modulate the replication of hepatitis C virus (HCV) and fibrogenesis. We investigated the influence of HIV tropism on liver fibrosis and the concentration of HCV RNA in HIV-HCV co-infected patients.<h4>Methods</h4>We used a phenotypic assay to assess HIV tropism in 172 HCV-HIV co-infected patients: one group (75 patients) had mild fibrosis (score ≤F2) and the other (97 patients) had severe fibrosis (score >F2). We also assessed the relationship between HIV tropism and HCV RNA concentration in all these patients. We also followed 34 of these patients for 3 years to determine the evolution of HIV tropism and liver fibrosis, estimated by liver stiffness.<h4>Results</h4>Initially, most patients (91.8%) received a potent antiretroviral therapy. CXCR4-using viruses were found in 29% of patients. The only factor associated with a CXCR4-using virus infection in multivariate analysis was the nadir of CD4 cells: <200/mm(3) (OR: 3.94, 95%CI: 1.39-11.14). The median HCV RNA concentrations in patients infected with R5 viruses, those with dual-mixed viruses and those with X4 viruses, were all similar. The prevalence of CXCR4-using viruses in patients with mild fibrosis (≤F2) (31%) and those with severe fibrosis (F3-F4) (28%, p = 0.6) was similar. Longitudinal analyses showed that the presence of CXCR4-using viruses did not increase the likelihood of fibrosis progression, evaluated by measuring liver stiffness.<h4>Conclusions</h4>The presence of CXCR4-using viruses in patients receiving a potent antiretroviral therapy does not influence HCV RNA concentration or liver fibrosis. |
| format |
article |
| author |
Florence Abravanel Stéphanie Raymond Elodie Pambrun Maria Winnock Philippe Bonnard Philippe Sogni Pascale Trimoulet François Dabis Dominique Salmon-Ceron Jacques Izopet ANRS CO13 HEPAVIH Study Group |
| author_facet |
Florence Abravanel Stéphanie Raymond Elodie Pambrun Maria Winnock Philippe Bonnard Philippe Sogni Pascale Trimoulet François Dabis Dominique Salmon-Ceron Jacques Izopet ANRS CO13 HEPAVIH Study Group |
| author_sort |
Florence Abravanel |
| title |
HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients. |
| title_short |
HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients. |
| title_full |
HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients. |
| title_fullStr |
HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients. |
| title_full_unstemmed |
HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients. |
| title_sort |
hiv-1 tropism and liver fibrosis in hiv-hcv co-infected patients. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/bab85cd44e4d4f14839ff1476abf7191 |
| work_keys_str_mv |
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