α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

α-Synuclein (αS) aggregation is a driver of several neurodegenerative disorders. Here, the authors identify a class of peptides that bind toxic αS oligomers and amyloid fibrils but not monomeric functional protein, and prevent further αS aggregation and associated cell damage.

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Main Authors: Jaime Santos, Pablo Gracia, Susanna Navarro, Samuel Peña-Díaz, Jordi Pujols, Nunilo Cremades, Irantzu Pallarès, Salvador Ventura
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/babb4836107c429db56c82e49b2776a5
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spelling oai:doaj.org-article:babb4836107c429db56c82e49b2776a52021-12-02T16:04:21Zα-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity10.1038/s41467-021-24039-22041-1723https://doaj.org/article/babb4836107c429db56c82e49b2776a52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24039-2https://doaj.org/toc/2041-1723α-Synuclein (αS) aggregation is a driver of several neurodegenerative disorders. Here, the authors identify a class of peptides that bind toxic αS oligomers and amyloid fibrils but not monomeric functional protein, and prevent further αS aggregation and associated cell damage.Jaime SantosPablo GraciaSusanna NavarroSamuel Peña-DíazJordi PujolsNunilo CremadesIrantzu PallarèsSalvador VenturaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jaime Santos
Pablo Gracia
Susanna Navarro
Samuel Peña-Díaz
Jordi Pujols
Nunilo Cremades
Irantzu Pallarès
Salvador Ventura
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
description α-Synuclein (αS) aggregation is a driver of several neurodegenerative disorders. Here, the authors identify a class of peptides that bind toxic αS oligomers and amyloid fibrils but not monomeric functional protein, and prevent further αS aggregation and associated cell damage.
format article
author Jaime Santos
Pablo Gracia
Susanna Navarro
Samuel Peña-Díaz
Jordi Pujols
Nunilo Cremades
Irantzu Pallarès
Salvador Ventura
author_facet Jaime Santos
Pablo Gracia
Susanna Navarro
Samuel Peña-Díaz
Jordi Pujols
Nunilo Cremades
Irantzu Pallarès
Salvador Ventura
author_sort Jaime Santos
title α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
title_short α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
title_full α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
title_fullStr α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
title_full_unstemmed α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
title_sort α-helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/babb4836107c429db56c82e49b2776a5
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AT susannanavarro ahelicalpeptidicscaffoldstotargetasynucleintoxicspecieswithnanomolaraffinity
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