Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients

Abstract Since the start of the novel coronavirus 2019 (COVID-19) pandemic, corticosteroid use has been the subject of debate. The available evidence is uncertain, and knowledge on the subject is evolving. The aim of our cohort study was to evaluate the association between corticosteroid therapy and...

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Autores principales:	Filippo Albani, Federica Fusina, Enza Granato, Cristina Capotosto, Claudia Ceracchi, Riccardo Gargaruti, Giovanni Santangelo, Luca Schiavone, Maria Salvatrice Taranto, Cinzia Tosati, Elena Vavassori, Giuseppe Natalini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/babde8d5383440d1a3578de4d3f1d5e9
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spelling	oai:doaj.org-article:babde8d5383440d1a3578de4d3f1d5e92021-12-02T14:12:42ZCorticosteroid treatment has no effect on hospital mortality in COVID-19 patients10.1038/s41598-020-80654-x2045-2322https://doaj.org/article/babde8d5383440d1a3578de4d3f1d5e92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80654-xhttps://doaj.org/toc/2045-2322Abstract Since the start of the novel coronavirus 2019 (COVID-19) pandemic, corticosteroid use has been the subject of debate. The available evidence is uncertain, and knowledge on the subject is evolving. The aim of our cohort study was to evaluate the association between corticosteroid therapy and hospital mortality, in patients hospitalized with COVID-19 after balancing for possible confounders. One thousand four hundred forty four patients were admitted to our hospital with a positive RT-PCR test for SARS-CoV-2, 559 patients (39%) were exposed to corticosteroids during hospital stay, 844 (61%) were not exposed to corticosteroids. In the cohort of patients exposed to corticosteroids, 171 (30.6%) died. In the cohort of patients not exposed to corticosteroids, 183 (21.7%) died (unadjusted p < 0.001). Nonetheless, exposure to corticosteroids was not associated with in-hospital mortality after balancing with overlap weight propensity score (adjusted p = 0.25). Patients in the corticosteroids cohort had a reduced risk of ICU admission (adjusted p < 0.001). Treatment with corticosteroids did not affect hospital mortality in patients with COVID-19 after balancing for confounders. A possible advantage of corticosteroid therapy was to reduce Intensive Care Unit admission, which could be useful in reducing pressure on Intensive Care Units in times of limited resources, as during the COVID-19 pandemic.Filippo AlbaniFederica FusinaEnza GranatoCristina CapotostoClaudia CeracchiRiccardo GargarutiGiovanni SantangeloLuca SchiavoneMaria Salvatrice TarantoCinzia TosatiElena VavassoriGiuseppe NataliniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Filippo Albani Federica Fusina Enza Granato Cristina Capotosto Claudia Ceracchi Riccardo Gargaruti Giovanni Santangelo Luca Schiavone Maria Salvatrice Taranto Cinzia Tosati Elena Vavassori Giuseppe Natalini Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients
description	Abstract Since the start of the novel coronavirus 2019 (COVID-19) pandemic, corticosteroid use has been the subject of debate. The available evidence is uncertain, and knowledge on the subject is evolving. The aim of our cohort study was to evaluate the association between corticosteroid therapy and hospital mortality, in patients hospitalized with COVID-19 after balancing for possible confounders. One thousand four hundred forty four patients were admitted to our hospital with a positive RT-PCR test for SARS-CoV-2, 559 patients (39%) were exposed to corticosteroids during hospital stay, 844 (61%) were not exposed to corticosteroids. In the cohort of patients exposed to corticosteroids, 171 (30.6%) died. In the cohort of patients not exposed to corticosteroids, 183 (21.7%) died (unadjusted p < 0.001). Nonetheless, exposure to corticosteroids was not associated with in-hospital mortality after balancing with overlap weight propensity score (adjusted p = 0.25). Patients in the corticosteroids cohort had a reduced risk of ICU admission (adjusted p < 0.001). Treatment with corticosteroids did not affect hospital mortality in patients with COVID-19 after balancing for confounders. A possible advantage of corticosteroid therapy was to reduce Intensive Care Unit admission, which could be useful in reducing pressure on Intensive Care Units in times of limited resources, as during the COVID-19 pandemic.
format	article
author	Filippo Albani Federica Fusina Enza Granato Cristina Capotosto Claudia Ceracchi Riccardo Gargaruti Giovanni Santangelo Luca Schiavone Maria Salvatrice Taranto Cinzia Tosati Elena Vavassori Giuseppe Natalini
author_facet	Filippo Albani Federica Fusina Enza Granato Cristina Capotosto Claudia Ceracchi Riccardo Gargaruti Giovanni Santangelo Luca Schiavone Maria Salvatrice Taranto Cinzia Tosati Elena Vavassori Giuseppe Natalini
author_sort	Filippo Albani
title	Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients
title_short	Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients
title_full	Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients
title_fullStr	Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients
title_full_unstemmed	Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients
title_sort	corticosteroid treatment has no effect on hospital mortality in covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/babde8d5383440d1a3578de4d3f1d5e9
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Corticosteroid treatment has no effect on hospital mortality in COVID-19 patients

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