Health related quality of life among patients with tuberculosis and HIV in Thailand.

<h4>Introduction</h4>Health utilities of tuberculosis (TB) patients may be diminished by side effects from medication, prolonged treatment duration, physical effects of the disease itself, and social stigma attached to the disease.<h4>Methods</h4>We collected health utility d...

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Autores principales: Wanitchaya Kittikraisak, Pritaporn Kingkaew, Yot Teerawattananon, Jomkwan Yothasamut, Supalert Natesuwan, Weerawat Manosuthi, Virasakdi Chongsuvivatwong, Sara J Whitehead
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Publicado: Public Library of Science (PLoS) 2012
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spelling oai:doaj.org-article:babe9ffd6f1845de84f3930c79fc46ad2021-11-18T07:30:29ZHealth related quality of life among patients with tuberculosis and HIV in Thailand.1932-620310.1371/journal.pone.0029775https://doaj.org/article/babe9ffd6f1845de84f3930c79fc46ad2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22253777/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Health utilities of tuberculosis (TB) patients may be diminished by side effects from medication, prolonged treatment duration, physical effects of the disease itself, and social stigma attached to the disease.<h4>Methods</h4>We collected health utility data from Thai patients who were on TB treatment or had been successfully treated for TB for the purpose of economic modeling. Structured questionnaire and EuroQol (EQ-5D) and EuroQol visual analog scale (EQ-VAS) instruments were used as data collection tools. We compared utility of patients with two co-morbidities calculated using multiplicative model (U(CAL)) with the direct measures and fitted Tobit regression models to examine factors predictive of health utility and to assess difference in health utilities of patients in various medical conditions.<h4>Results</h4>Of 222 patients analyzed, 138 (62%) were male; median age at enrollment was 40 years (interquartile range [IQR], 35-47). Median monthly household income was 6,000 Baht (187 US$; IQR, 4,000-15,000 Baht [125-469 US$]). Concordance correlation coefficient between utilities measured using EQ-5D and EQ-VAS (U(EQ-5D) and U(VAS), respectively) was 0.6. U(CAL) for HIV-infected TB patients was statistically different from the measured U(EQ-5D) (p-value<0.01) and U(VAS) (p-value<0.01). In tobit regression analysis, factors independently predictive of U(EQ-5D) included age and monthly household income. Patients aged ≥40 years old rated U(EQ-5D) significantly lower than younger persons. Higher U(EQ-5D) was significantly associated with higher monthly household income in a dose response fashion. The median U(EQ-5D) was highest among patients who had been successfully treated for TB and lowest among multi-drug resistant TB (MDR-TB) patients who were on treatment.<h4>Conclusions</h4>U(CAL) of patients with two co-morbidities overestimated the measured utilities, warranting further research of how best to estimate utilities of patients with such conditions. TB and MDR-TB treatments impacted on patients' self perceived health status. This effect diminished after successful treatment.Wanitchaya KittikraisakPritaporn KingkaewYot TeerawattananonJomkwan YothasamutSupalert NatesuwanWeerawat ManosuthiVirasakdi ChongsuvivatwongSara J WhiteheadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29775 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Wanitchaya Kittikraisak
Pritaporn Kingkaew
Yot Teerawattananon
Jomkwan Yothasamut
Supalert Natesuwan
Weerawat Manosuthi
Virasakdi Chongsuvivatwong
Sara J Whitehead
Health related quality of life among patients with tuberculosis and HIV in Thailand.
description <h4>Introduction</h4>Health utilities of tuberculosis (TB) patients may be diminished by side effects from medication, prolonged treatment duration, physical effects of the disease itself, and social stigma attached to the disease.<h4>Methods</h4>We collected health utility data from Thai patients who were on TB treatment or had been successfully treated for TB for the purpose of economic modeling. Structured questionnaire and EuroQol (EQ-5D) and EuroQol visual analog scale (EQ-VAS) instruments were used as data collection tools. We compared utility of patients with two co-morbidities calculated using multiplicative model (U(CAL)) with the direct measures and fitted Tobit regression models to examine factors predictive of health utility and to assess difference in health utilities of patients in various medical conditions.<h4>Results</h4>Of 222 patients analyzed, 138 (62%) were male; median age at enrollment was 40 years (interquartile range [IQR], 35-47). Median monthly household income was 6,000 Baht (187 US$; IQR, 4,000-15,000 Baht [125-469 US$]). Concordance correlation coefficient between utilities measured using EQ-5D and EQ-VAS (U(EQ-5D) and U(VAS), respectively) was 0.6. U(CAL) for HIV-infected TB patients was statistically different from the measured U(EQ-5D) (p-value<0.01) and U(VAS) (p-value<0.01). In tobit regression analysis, factors independently predictive of U(EQ-5D) included age and monthly household income. Patients aged ≥40 years old rated U(EQ-5D) significantly lower than younger persons. Higher U(EQ-5D) was significantly associated with higher monthly household income in a dose response fashion. The median U(EQ-5D) was highest among patients who had been successfully treated for TB and lowest among multi-drug resistant TB (MDR-TB) patients who were on treatment.<h4>Conclusions</h4>U(CAL) of patients with two co-morbidities overestimated the measured utilities, warranting further research of how best to estimate utilities of patients with such conditions. TB and MDR-TB treatments impacted on patients' self perceived health status. This effect diminished after successful treatment.
format article
author Wanitchaya Kittikraisak
Pritaporn Kingkaew
Yot Teerawattananon
Jomkwan Yothasamut
Supalert Natesuwan
Weerawat Manosuthi
Virasakdi Chongsuvivatwong
Sara J Whitehead
author_facet Wanitchaya Kittikraisak
Pritaporn Kingkaew
Yot Teerawattananon
Jomkwan Yothasamut
Supalert Natesuwan
Weerawat Manosuthi
Virasakdi Chongsuvivatwong
Sara J Whitehead
author_sort Wanitchaya Kittikraisak
title Health related quality of life among patients with tuberculosis and HIV in Thailand.
title_short Health related quality of life among patients with tuberculosis and HIV in Thailand.
title_full Health related quality of life among patients with tuberculosis and HIV in Thailand.
title_fullStr Health related quality of life among patients with tuberculosis and HIV in Thailand.
title_full_unstemmed Health related quality of life among patients with tuberculosis and HIV in Thailand.
title_sort health related quality of life among patients with tuberculosis and hiv in thailand.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/babe9ffd6f1845de84f3930c79fc46ad
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