Vascular targeted nanotherapeutic approach for obesity treatment

Nicole Remaliah Samantha Sibuyi,1 Mervin Meyer,1 Martin Opiyo Onani,2 Amanda Skepu,3 Abram Madimabe Madiehe1 1Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa; 2Organome...

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Autores principales:	Sibuyi NRS, Meyer M, Onani MO, Skepu A, Madiehe AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Adipose Tissue Angiogenesis Nanomedicine Obesity Prohibitin Targeted drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bac45653b0a344fdb0cff2e6848f40d3
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spelling	oai:doaj.org-article:bac45653b0a344fdb0cff2e6848f40d32021-12-02T04:57:08ZVascular targeted nanotherapeutic approach for obesity treatment1178-2013https://doaj.org/article/bac45653b0a344fdb0cff2e6848f40d32018-11-01T00:00:00Zhttps://www.dovepress.com/vascular-targeted-nanotherapeutic-approach-for-obesity-treatment-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nicole Remaliah Samantha Sibuyi,1 Mervin Meyer,1 Martin Opiyo Onani,2 Amanda Skepu,3 Abram Madimabe Madiehe1 1Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa; 2Organometallics and Nanomaterials, Department of Chemistry, University of the Western Cape, Bellville, South Africa; 3Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Advanced Materials Division, Mintek, Johannesburg, South Africa Abstract: Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases, such as type 2 diabetes, cancer, and cardiovascular diseases. Pharmacotherapy remains the mainstay for the management of obesity; however, its usefulness is limited due to poor drug efficacy, non-specificity and toxic side effects. Therefore, novel approaches that could provide insights into obesity and obesity-associated diseases as well as development of novel anti-obesity treatment modalities or improvement on the existing drugs are necessary. While the ideal treatment of obesity should involve early intervention in susceptible individuals, targeted nanotherapy potentially provides a fresh perspective that might be better than the current conventional therapies. Independent studies have shown improved drug efficacy by using prohibitin (PHB)-targeted therapy in obese rodents and non-human primates, thus providing a proof of concept that targeted nanotherapy can be a feasible treatment for obesity. This review presents a brief global survey of obesity, its impact on human health, its current treatment and their limitations, and the role of angiogenesis and PHB in the development of obesity. Finally, the role and potential use of nanotechnology coupled with targeted drug delivery in the treatment of obesity are discussed. Keywords: adipose tissue, angiogenesis, nanomedicine, obesity, prohibitin, targeted drug deliverySibuyi NRSMeyer MOnani MOSkepu AMadiehe AMDove Medical PressarticleAdipose TissueAngiogenesisNanomedicineObesityProhibitinTargeted drug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7915-7929 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adipose Tissue Angiogenesis Nanomedicine Obesity Prohibitin Targeted drug delivery Medicine (General) R5-920
spellingShingle	Adipose Tissue Angiogenesis Nanomedicine Obesity Prohibitin Targeted drug delivery Medicine (General) R5-920 Sibuyi NRS Meyer M Onani MO Skepu A Madiehe AM Vascular targeted nanotherapeutic approach for obesity treatment
description	Nicole Remaliah Samantha Sibuyi,1 Mervin Meyer,1 Martin Opiyo Onani,2 Amanda Skepu,3 Abram Madimabe Madiehe1 1Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Department of Biotechnology, University of the Western Cape, Bellville, South Africa; 2Organometallics and Nanomaterials, Department of Chemistry, University of the Western Cape, Bellville, South Africa; 3Department of Science and Technology/Mintek Nanotechnology Innovation Centre, Biolabels Unit, Advanced Materials Division, Mintek, Johannesburg, South Africa Abstract: Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases, such as type 2 diabetes, cancer, and cardiovascular diseases. Pharmacotherapy remains the mainstay for the management of obesity; however, its usefulness is limited due to poor drug efficacy, non-specificity and toxic side effects. Therefore, novel approaches that could provide insights into obesity and obesity-associated diseases as well as development of novel anti-obesity treatment modalities or improvement on the existing drugs are necessary. While the ideal treatment of obesity should involve early intervention in susceptible individuals, targeted nanotherapy potentially provides a fresh perspective that might be better than the current conventional therapies. Independent studies have shown improved drug efficacy by using prohibitin (PHB)-targeted therapy in obese rodents and non-human primates, thus providing a proof of concept that targeted nanotherapy can be a feasible treatment for obesity. This review presents a brief global survey of obesity, its impact on human health, its current treatment and their limitations, and the role of angiogenesis and PHB in the development of obesity. Finally, the role and potential use of nanotechnology coupled with targeted drug delivery in the treatment of obesity are discussed. Keywords: adipose tissue, angiogenesis, nanomedicine, obesity, prohibitin, targeted drug delivery
format	article
author	Sibuyi NRS Meyer M Onani MO Skepu A Madiehe AM
author_facet	Sibuyi NRS Meyer M Onani MO Skepu A Madiehe AM
author_sort	Sibuyi NRS
title	Vascular targeted nanotherapeutic approach for obesity treatment
title_short	Vascular targeted nanotherapeutic approach for obesity treatment
title_full	Vascular targeted nanotherapeutic approach for obesity treatment
title_fullStr	Vascular targeted nanotherapeutic approach for obesity treatment
title_full_unstemmed	Vascular targeted nanotherapeutic approach for obesity treatment
title_sort	vascular targeted nanotherapeutic approach for obesity treatment
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/bac45653b0a344fdb0cff2e6848f40d3
work_keys_str_mv	AT sibuyinrs vasculartargetednanotherapeuticapproachforobesitytreatment AT meyerm vasculartargetednanotherapeuticapproachforobesitytreatment AT onanimo vasculartargetednanotherapeuticapproachforobesitytreatment AT skepua vasculartargetednanotherapeuticapproachforobesitytreatment AT madieheam vasculartargetednanotherapeuticapproachforobesitytreatment
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Vascular targeted nanotherapeutic approach for obesity treatment

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