Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts

Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs),...

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Autores principales:	Chuan Sun, Zheng Huang, Houbing Qin, Jing Zhang, Sanying Wang, Xiaogang Xu, Shibo Ying, Genxiang Mao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	electromagnetic fields (EMFs) aging DNA damage pulsed electromagnetic field cellular senescence human fetal lung fibroblasts Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/bac5254e1b5d4158b6465bb432750f46
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spelling	oai:doaj.org-article:bac5254e1b5d4158b6465bb432750f462021-11-11T09:14:10ZExposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts2296-256510.3389/fpubh.2021.761069https://doaj.org/article/bac5254e1b5d4158b6465bb432750f462021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.761069/fullhttps://doaj.org/toc/2296-2565Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells.Chuan SunZheng HuangHoubing QinJing ZhangSanying WangXiaogang XuShibo YingGenxiang MaoFrontiers Media S.A.articleelectromagnetic fields (EMFs)agingDNA damagepulsed electromagnetic fieldcellular senescencehuman fetal lung fibroblastsPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	electromagnetic fields (EMFs) aging DNA damage pulsed electromagnetic field cellular senescence human fetal lung fibroblasts Public aspects of medicine RA1-1270
spellingShingle	electromagnetic fields (EMFs) aging DNA damage pulsed electromagnetic field cellular senescence human fetal lung fibroblasts Public aspects of medicine RA1-1270 Chuan Sun Zheng Huang Houbing Qin Jing Zhang Sanying Wang Xiaogang Xu Shibo Ying Genxiang Mao Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
description	Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells.
format	article
author	Chuan Sun Zheng Huang Houbing Qin Jing Zhang Sanying Wang Xiaogang Xu Shibo Ying Genxiang Mao
author_facet	Chuan Sun Zheng Huang Houbing Qin Jing Zhang Sanying Wang Xiaogang Xu Shibo Ying Genxiang Mao
author_sort	Chuan Sun
title	Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_short	Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_full	Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_fullStr	Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_full_unstemmed	Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts
title_sort	exposure to 10 hz pulsed magnetic fields do not induce cellular senescence in human fetal lung fibroblasts
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bac5254e1b5d4158b6465bb432750f46
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Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts

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