Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy

Aim: To relate quantitative magnetic resonance imaging (MRI) of ankle plantar flexor muscles to clinical functional tests in adults with cerebral palsy (CP) and neurologically intact (NI) adults.Methods: Eleven adults with CP (aged 41 ± 12, GMFCS level I-II) and 11 NI adults (aged 35 ± 10) participa...

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Autores principales:	Christian Svane, Christian Riis Forman, Aqella Rasul, Christian Hammer Nielsen, Jens Bo Nielsen, Jakob Lorentzen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	magnetic resonance imaging (MRI) cerebral palsy muscle composition muscle size fat fraction countermovement jump Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bac5328b3bf545519e6b5e7deeb65680
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spelling	oai:doaj.org-article:bac5328b3bf545519e6b5e7deeb656802021-11-10T05:39:18ZQuantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy1664-229510.3389/fneur.2021.771375https://doaj.org/article/bac5328b3bf545519e6b5e7deeb656802021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.771375/fullhttps://doaj.org/toc/1664-2295Aim: To relate quantitative magnetic resonance imaging (MRI) of ankle plantar flexor muscles to clinical functional tests in adults with cerebral palsy (CP) and neurologically intact (NI) adults.Methods: Eleven adults with CP (aged 41 ± 12, GMFCS level I-II) and 11 NI adults (aged 35 ± 10) participated in this case-control study. We used MRI to assess muscle volume and composition of the triceps surae muscles. We quantified muscle function as maximal voluntary plantarflexion (MVC) torque and countermovement jump (CMJ) height.Results: Compared to NI adults, the MRI intramuscular fat fraction estimate was significantly higher and MRI muscle volume and functional abilities (MVC and CMJ) significantly lower in adults with CP. In NI adults, but not adults with CP, MRI muscle volume correlated significantly with MVC and CMJ. In adults with CP, the estimate of intramuscular fat levels correlated significantly with jump height in a CMJ.Discussion: This study shows reduced muscle volume and altered muscle composition in adults with CP. Muscle composition appears to provide a better marker than muscle volume of reduced muscle function and impaired performance in this population. Measurements of muscle composition could be used in the assessment of neuromuscular impairments and in the determination of rehabilitation protocols in individuals with neurological disorders.Christian SvaneChristian SvaneChristian Riis FormanChristian Riis FormanAqella RasulChristian Hammer NielsenJens Bo NielsenJens Bo NielsenJakob LorentzenJakob LorentzenFrontiers Media S.A.articlemagnetic resonance imaging (MRI)cerebral palsymuscle compositionmuscle sizefat fractioncountermovement jumpNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic resonance imaging (MRI) cerebral palsy muscle composition muscle size fat fraction countermovement jump Neurology. Diseases of the nervous system RC346-429
spellingShingle	magnetic resonance imaging (MRI) cerebral palsy muscle composition muscle size fat fraction countermovement jump Neurology. Diseases of the nervous system RC346-429 Christian Svane Christian Svane Christian Riis Forman Christian Riis Forman Aqella Rasul Christian Hammer Nielsen Jens Bo Nielsen Jens Bo Nielsen Jakob Lorentzen Jakob Lorentzen Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
description	Aim: To relate quantitative magnetic resonance imaging (MRI) of ankle plantar flexor muscles to clinical functional tests in adults with cerebral palsy (CP) and neurologically intact (NI) adults.Methods: Eleven adults with CP (aged 41 ± 12, GMFCS level I-II) and 11 NI adults (aged 35 ± 10) participated in this case-control study. We used MRI to assess muscle volume and composition of the triceps surae muscles. We quantified muscle function as maximal voluntary plantarflexion (MVC) torque and countermovement jump (CMJ) height.Results: Compared to NI adults, the MRI intramuscular fat fraction estimate was significantly higher and MRI muscle volume and functional abilities (MVC and CMJ) significantly lower in adults with CP. In NI adults, but not adults with CP, MRI muscle volume correlated significantly with MVC and CMJ. In adults with CP, the estimate of intramuscular fat levels correlated significantly with jump height in a CMJ.Discussion: This study shows reduced muscle volume and altered muscle composition in adults with CP. Muscle composition appears to provide a better marker than muscle volume of reduced muscle function and impaired performance in this population. Measurements of muscle composition could be used in the assessment of neuromuscular impairments and in the determination of rehabilitation protocols in individuals with neurological disorders.
format	article
author	Christian Svane Christian Svane Christian Riis Forman Christian Riis Forman Aqella Rasul Christian Hammer Nielsen Jens Bo Nielsen Jens Bo Nielsen Jakob Lorentzen Jakob Lorentzen
author_facet	Christian Svane Christian Svane Christian Riis Forman Christian Riis Forman Aqella Rasul Christian Hammer Nielsen Jens Bo Nielsen Jens Bo Nielsen Jakob Lorentzen Jakob Lorentzen
author_sort	Christian Svane
title	Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
title_short	Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
title_full	Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
title_fullStr	Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
title_full_unstemmed	Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy
title_sort	quantitative mri and clinical assessment of muscle function in adults with cerebral palsy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bac5328b3bf545519e6b5e7deeb65680
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Quantitative MRI and Clinical Assessment of Muscle Function in Adults With Cerebral Palsy

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