TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing

The PIWI protein MIWI2 counteracts transposon activity by transcriptional silencing in the mammalian germline. Here, the authors show that TEX15 interacts with MIWI2 and is required for piRNA-directed methylation of transposable elements in male germ cells.

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Autores principales:	Theresa Schöpp, Ansgar Zoch, Rebecca V. Berrens, Tania Auchynnikava, Yuka Kabayama, Lina Vasiliauskaitė, Juri Rappsilber, Robin C. Allshire, Dónal O’Carroll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bac7f2c5d49b420186c693051a386765
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spelling	oai:doaj.org-article:bac7f2c5d49b420186c693051a3867652021-12-02T16:25:00ZTEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing10.1038/s41467-020-17372-52041-1723https://doaj.org/article/bac7f2c5d49b420186c693051a3867652020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17372-5https://doaj.org/toc/2041-1723The PIWI protein MIWI2 counteracts transposon activity by transcriptional silencing in the mammalian germline. Here, the authors show that TEX15 interacts with MIWI2 and is required for piRNA-directed methylation of transposable elements in male germ cells.Theresa SchöppAnsgar ZochRebecca V. BerrensTania AuchynnikavaYuka KabayamaLina VasiliauskaitėJuri RappsilberRobin C. AllshireDónal O’CarrollNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Theresa Schöpp Ansgar Zoch Rebecca V. Berrens Tania Auchynnikava Yuka Kabayama Lina Vasiliauskaitė Juri Rappsilber Robin C. Allshire Dónal O’Carroll TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
description	The PIWI protein MIWI2 counteracts transposon activity by transcriptional silencing in the mammalian germline. Here, the authors show that TEX15 interacts with MIWI2 and is required for piRNA-directed methylation of transposable elements in male germ cells.
format	article
author	Theresa Schöpp Ansgar Zoch Rebecca V. Berrens Tania Auchynnikava Yuka Kabayama Lina Vasiliauskaitė Juri Rappsilber Robin C. Allshire Dónal O’Carroll
author_facet	Theresa Schöpp Ansgar Zoch Rebecca V. Berrens Tania Auchynnikava Yuka Kabayama Lina Vasiliauskaitė Juri Rappsilber Robin C. Allshire Dónal O’Carroll
author_sort	Theresa Schöpp
title	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
title_short	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
title_full	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
title_fullStr	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
title_full_unstemmed	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
title_sort	tex15 is an essential executor of miwi2-directed transposon dna methylation and silencing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bac7f2c5d49b420186c693051a386765
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TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing

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